High-dose lorazepam therapy for status epilepticus in a pediatric patient

H. M. Reincke, R. L. Gilmore, R. J. Kuhn

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


This report details the management of status epilepticus with high-dose lorazepam in a 14-year-old patient who was receiving oral clonazepam, ethosuximide, and phenobarbital for an intractable seizure disorder. Although respiratory depression is a frequently cited potential complication of therapy, it did not occur in this patient despite an extraordinarily high total dose of lorazepam, possibly because of tolerance associated with benzodiazepine-receptor down-regulation in this patient's chronic clonazepam therapy. Aggressive dosing of a benzodiazepine may be required for patients receiving chronic benzodiazepine therapy.

Original languageEnglish
Pages (from-to)889-890
Number of pages2
JournalDrug intelligence & clinical pharmacy
Issue number11
StatePublished - 1988

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics (all)
  • Pharmacology (medical)


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