TY - JOUR
T1 - High-dose lorazepam therapy for status epilepticus in a pediatric patient
AU - Reincke, H. M.
AU - Gilmore, R. L.
AU - Kuhn, R. J.
PY - 1988
Y1 - 1988
N2 - This report details the management of status epilepticus with high-dose lorazepam in a 14-year-old patient who was receiving oral clonazepam, ethosuximide, and phenobarbital for an intractable seizure disorder. Although respiratory depression is a frequently cited potential complication of therapy, it did not occur in this patient despite an extraordinarily high total dose of lorazepam, possibly because of tolerance associated with benzodiazepine-receptor down-regulation in this patient's chronic clonazepam therapy. Aggressive dosing of a benzodiazepine may be required for patients receiving chronic benzodiazepine therapy.
AB - This report details the management of status epilepticus with high-dose lorazepam in a 14-year-old patient who was receiving oral clonazepam, ethosuximide, and phenobarbital for an intractable seizure disorder. Although respiratory depression is a frequently cited potential complication of therapy, it did not occur in this patient despite an extraordinarily high total dose of lorazepam, possibly because of tolerance associated with benzodiazepine-receptor down-regulation in this patient's chronic clonazepam therapy. Aggressive dosing of a benzodiazepine may be required for patients receiving chronic benzodiazepine therapy.
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U2 - 10.1177/106002808802201112
DO - 10.1177/106002808802201112
M3 - Article
C2 - 3234256
AN - SCOPUS:0023692238
SN - 0012-6578
VL - 22
SP - 889
EP - 890
JO - Drug Intelligence and Clinical Pharmacy
JF - Drug Intelligence and Clinical Pharmacy
IS - 11
ER -