High-fat diet acutely affects circadian organisation and eating behavior

Julie S. Pendergast, Katrina L. Branecky, William Yang, Kate L.J. Ellacott, Kevin D. Niswender, Shin Yamazaki

Research output: Contribution to journalArticlepeer-review

143 Scopus citations


The organisation of timing in mammalian circadian clocks optimally coordinates behavior and physiology with daily environmental cycles. Chronic consumption of a high-fat diet alters circadian rhythms, but the acute effects on circadian organisation are unknown. To investigate the proximate effects of a high-fat diet on circadian physiology, we examined the phase relationship between central and peripheral clocks in mice fed a high-fat diet for 1 week. By 7 days, the phase of the liver rhythm was markedly advanced (by 5 h), whereas rhythms in other tissues were not affected. In addition, immediately upon consumption of a high-fat diet, the daily rhythm of eating behavior was altered. As the tissue rhythm of the suprachiasmatic nucleus was not affected by 1 week of high-fat diet consumption, the brain nuclei mediating the effect of a high-fat diet on eating behavior are likely to be downstream of the suprachiasmatic nucleus.

Original languageEnglish
Pages (from-to)1350-1356
Number of pages7
JournalEuropean Journal of Neuroscience
Issue number8
StatePublished - Apr 2013


  • C57BL/6J
  • Hypothalamus
  • Liver
  • Luciferase reporter
  • Mouse
  • Obesity

ASJC Scopus subject areas

  • General Neuroscience


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