TY - JOUR
T1 - High-fat diet acutely affects circadian organisation and eating behavior
AU - Pendergast, Julie S.
AU - Branecky, Katrina L.
AU - Yang, William
AU - Ellacott, Kate L.J.
AU - Niswender, Kevin D.
AU - Yamazaki, Shin
PY - 2013/4
Y1 - 2013/4
N2 - The organisation of timing in mammalian circadian clocks optimally coordinates behavior and physiology with daily environmental cycles. Chronic consumption of a high-fat diet alters circadian rhythms, but the acute effects on circadian organisation are unknown. To investigate the proximate effects of a high-fat diet on circadian physiology, we examined the phase relationship between central and peripheral clocks in mice fed a high-fat diet for 1 week. By 7 days, the phase of the liver rhythm was markedly advanced (by 5 h), whereas rhythms in other tissues were not affected. In addition, immediately upon consumption of a high-fat diet, the daily rhythm of eating behavior was altered. As the tissue rhythm of the suprachiasmatic nucleus was not affected by 1 week of high-fat diet consumption, the brain nuclei mediating the effect of a high-fat diet on eating behavior are likely to be downstream of the suprachiasmatic nucleus.
AB - The organisation of timing in mammalian circadian clocks optimally coordinates behavior and physiology with daily environmental cycles. Chronic consumption of a high-fat diet alters circadian rhythms, but the acute effects on circadian organisation are unknown. To investigate the proximate effects of a high-fat diet on circadian physiology, we examined the phase relationship between central and peripheral clocks in mice fed a high-fat diet for 1 week. By 7 days, the phase of the liver rhythm was markedly advanced (by 5 h), whereas rhythms in other tissues were not affected. In addition, immediately upon consumption of a high-fat diet, the daily rhythm of eating behavior was altered. As the tissue rhythm of the suprachiasmatic nucleus was not affected by 1 week of high-fat diet consumption, the brain nuclei mediating the effect of a high-fat diet on eating behavior are likely to be downstream of the suprachiasmatic nucleus.
KW - C57BL/6J
KW - Hypothalamus
KW - Liver
KW - Luciferase reporter
KW - Mouse
KW - Obesity
UR - http://www.scopus.com/inward/record.url?scp=84876329409&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84876329409&partnerID=8YFLogxK
U2 - 10.1111/ejn.12133
DO - 10.1111/ejn.12133
M3 - Article
C2 - 23331763
AN - SCOPUS:84876329409
SN - 0953-816X
VL - 37
SP - 1350
EP - 1356
JO - European Journal of Neuroscience
JF - European Journal of Neuroscience
IS - 8
ER -