Abnormal meal timing, like skipping breakfast and late-night snacking, is associated with obesity in humans. Disruption of daily eating rhythms also contributes to obesity in mice. When fed a high-fat diet, male C57BL/6J mice have disrupted eating behavior rhythms and they become obese. In contrast to obesity-prone C57BL/6J mice, some inbred strains of mice are resistant to high-fat diet-induced obesity. In this study, we sought to determine whether there are distinct effects of high-fat feeding on daily eating behavior rhythms in obesity-prone and obesity-resistant male mice. Male obesity-prone (C57BL/6J and 129X1/SvJ) and obesity-resistant (SWR/J and BALB/cJ) mice were fed low-fat diet or high-fat diet for 6 wk. Consistent with previous studies, obesity-prone male mice gained more weight and adiposity during high-fat diet feeding than obesity-resistant male mice. The amplitude of the daily rhythm of eating behavior was markedly attenuated in male obesity-prone mice fed high-fat diet, but not in obesity-resistant males. In contrast, high-fat feeding did not differentially affect locomotor activity rhythms in obesity-prone and obesity-resistant male mice. Together, these data suggest that regulation of the daily rhythm of eating may underlie the propensity to develop diet-induced obesity in male mice.
|Journal||American Journal of Physiology - Regulatory Integrative and Comparative Physiology|
|State||Published - Apr 2021|
Bibliographical noteFunding Information:
This research was funded by National Institutes of Health (NIH) Grants K01DK098321 (to J.S.P.), the Washington University Diabetes Research Center P30DK020579 (Pilot Award to J.S.P.), P30GM127211, the National Center for Advancing Translational Sciences UL1TR001998, as well as the Gertrude F. Ribble Grant (to O.O. and J.M.C), the American Physiological Society Undergraduate Summer Research Fellowship (to J.D.L.), and the University of Kentucky.
© 2021 the American Physiological Society
- Eating behavior rhythm
- High-fat diet
ASJC Scopus subject areas
- Physiology (medical)