High-Grade Urothelial Carcinoma (HGUC)

Momin T. Siddiqui; Derek B. Allison; Guido Fadda; Jee Young Han; Patrick J. McIntire; Christopher L. Owens; Z. Laura Tabatabai; Toyonori Tsuzuki; Mingjuan Lisa Zhang

doi:10.1007/978-3-030-88686-8_6

High-Grade Urothelial Carcinoma (HGUC)

Momin T. Siddiqui, Derek B. Allison, Guido Fadda, Jee Young Han, Patrick J. McIntire, Christopher L. Owens, Z. Laura Tabatabai, Toyonori Tsuzuki, Mingjuan Lisa Zhang

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

9 Scopus citations

Abstract

High-grade urothelial carcinoma (HGUC) is diagnosed using major criteria which include high N/C ratio, irregular nuclear membranes, and coarse chromatin. TPS second edition recognizes these criteria to be stringent in order to normalize the cytomorphologic heterogeneity of HGUC on urine samples and has included notable variances which may be present in urine samples. These variances are most notably N/C ratios that have a wide range in tumor cells and hypochromasia in select cases, along with HGUC sub-types, all of which impact cytologic interpretation. Degeneration of tumor cells also affects diagnosis of HGUC. The recognition of the major criteria and the variances will help in diagnosis of HGUC on cytologic specimens.

Original language	English
Title of host publication	The Paris System for Reporting Urinary Cytology
Subtitle of host publication	Second Edition
Pages	97-114
Number of pages	18
ISBN (Electronic)	9783030886868
DOIs	https://doi.org/10.1007/978-3-030-88686-8_6
State	Published - Jan 1 2022

Bibliographical note

Publisher Copyright:
© Springer Nature Switzerland AG 2022.

Keywords

Bladder barbotage
Bladder washing
HGUC
High N/C ratio
Hyperchromasia
Malignant cells
Urothelial carcinoma
Voided urines

ASJC Scopus subject areas

General Medicine

Access to Document

10.1007/978-3-030-88686-8_6

Cite this

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title = "High-Grade Urothelial Carcinoma (HGUC)",

abstract = "High-grade urothelial carcinoma (HGUC) is diagnosed using major criteria which include high N/C ratio, irregular nuclear membranes, and coarse chromatin. TPS second edition recognizes these criteria to be stringent in order to normalize the cytomorphologic heterogeneity of HGUC on urine samples and has included notable variances which may be present in urine samples. These variances are most notably N/C ratios that have a wide range in tumor cells and hypochromasia in select cases, along with HGUC sub-types, all of which impact cytologic interpretation. Degeneration of tumor cells also affects diagnosis of HGUC. The recognition of the major criteria and the variances will help in diagnosis of HGUC on cytologic specimens.",

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AU - McIntire, Patrick J.

AU - Owens, Christopher L.

AU - Laura Tabatabai, Z.

AU - Tsuzuki, Toyonori

AU - Zhang, Mingjuan Lisa

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High-Grade Urothelial Carcinoma (HGUC)

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

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Cite this