Scavenger receptor class B type I (SR-BI) has been linked to the development and progression of breast cancer. However, its clinical significance in breast cancer remains unclear. Here, we evaluated SR-BI expression in a well-characterized breast cancer tissue microarray by immunohistochemistry. High SR-BI expression was observed in 54 % of all breast cancer cases and was significantly associated with advanced pTNM stage (P = 0.002), larger tumor size (P = 0.023), lymph node metastasis (P = 0.012), and the absence of ER (P = 0.014). The Kaplan–Meier survival analysis revealed that patients with high SR-BI expression had significantly shorter overall survival (OS) (P = 0.004). Moreover, multivariate analysis with adjustment for other prognostic factors confirmed that SR-BI was an independent prognostic factor for patient outcome (P = 0.017). Overall, our study demonstrated that high SR-BI expression was related to conventional parameters indicative of more aggressive tumor type and may serve as a new prognostic marker for poor clinical outcome in human breast cancer.
|Number of pages||8|
|State||Published - Mar 1 2016|
Bibliographical noteFunding Information:
This work was supported by grants from the National Natural Science Foundation of China (No. 81201865 and 81202307), and Shandong Science and Technology Development Planning (No. 2011GSF11843 and 2012G0021822).
© 2015, International Society of Oncology and BioMarkers (ISOBM).
- Breast cancer
- Scavenger receptor class B type I
ASJC Scopus subject areas
- Medicine (all)