High scavenger receptor class B type I expression is related to tumor aggressiveness and poor prognosis in breast cancer

Baoying Yuan; Changshun Wu; Xingwen Wang; Dan Wang; Huiling Liu; Ling Guo; Xiang An Li; Junqing Han; Hong Feng

doi:10.1007/s13277-015-4141-4

High scavenger receptor class B type I expression is related to tumor aggressiveness and poor prognosis in breast cancer

Baoying Yuan, Changshun Wu, Xingwen Wang, Dan Wang, Huiling Liu, Ling Guo, Xiang An Li, Junqing Han, Hong Feng

Physiology

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

Scavenger receptor class B type I (SR-BI) has been linked to the development and progression of breast cancer. However, its clinical significance in breast cancer remains unclear. Here, we evaluated SR-BI expression in a well-characterized breast cancer tissue microarray by immunohistochemistry. High SR-BI expression was observed in 54 % of all breast cancer cases and was significantly associated with advanced pTNM stage (P = 0.002), larger tumor size (P = 0.023), lymph node metastasis (P = 0.012), and the absence of ER (P = 0.014). The Kaplan–Meier survival analysis revealed that patients with high SR-BI expression had significantly shorter overall survival (OS) (P = 0.004). Moreover, multivariate analysis with adjustment for other prognostic factors confirmed that SR-BI was an independent prognostic factor for patient outcome (P = 0.017). Overall, our study demonstrated that high SR-BI expression was related to conventional parameters indicative of more aggressive tumor type and may serve as a new prognostic marker for poor clinical outcome in human breast cancer.

Original language	English
Pages (from-to)	3581-3588
Number of pages	8
Journal	Tumor Biology
Volume	37
Issue number	3
DOIs	https://doi.org/10.1007/s13277-015-4141-4
State	Published - Mar 1 2016

Bibliographical note

Funding Information:
This work was supported by grants from the National Natural Science Foundation of China (No. 81201865 and 81202307), and Shandong Science and Technology Development Planning (No. 2011GSF11843 and 2012G0021822).

Publisher Copyright:
© 2015, International Society of Oncology and BioMarkers (ISOBM).

Keywords

Breast cancer
Immunohistochemistry
Prognosis
Scavenger receptor class B type I

ASJC Scopus subject areas

Medicine (all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/s13277-015-4141-4

Cite this

@article{47a50aecde204c2d82b9fe59992ad32b,

title = "High scavenger receptor class B type I expression is related to tumor aggressiveness and poor prognosis in breast cancer",

abstract = "Scavenger receptor class B type I (SR-BI) has been linked to the development and progression of breast cancer. However, its clinical significance in breast cancer remains unclear. Here, we evaluated SR-BI expression in a well-characterized breast cancer tissue microarray by immunohistochemistry. High SR-BI expression was observed in 54 % of all breast cancer cases and was significantly associated with advanced pTNM stage (P = 0.002), larger tumor size (P = 0.023), lymph node metastasis (P = 0.012), and the absence of ER (P = 0.014). The Kaplan–Meier survival analysis revealed that patients with high SR-BI expression had significantly shorter overall survival (OS) (P = 0.004). Moreover, multivariate analysis with adjustment for other prognostic factors confirmed that SR-BI was an independent prognostic factor for patient outcome (P = 0.017). Overall, our study demonstrated that high SR-BI expression was related to conventional parameters indicative of more aggressive tumor type and may serve as a new prognostic marker for poor clinical outcome in human breast cancer.",

keywords = "Breast cancer, Immunohistochemistry, Prognosis, Scavenger receptor class B type I",

author = "Baoying Yuan and Changshun Wu and Xingwen Wang and Dan Wang and Huiling Liu and Ling Guo and Li, {Xiang An} and Junqing Han and Hong Feng",

note = "Funding Information: This work was supported by grants from the National Natural Science Foundation of China (No. 81201865 and 81202307), and Shandong Science and Technology Development Planning (No. 2011GSF11843 and 2012G0021822). Publisher Copyright: {\textcopyright} 2015, International Society of Oncology and BioMarkers (ISOBM).",

year = "2016",

month = mar,

day = "1",

doi = "10.1007/s13277-015-4141-4",

language = "English",

volume = "37",

pages = "3581--3588",

number = "3",

}

TY - JOUR

T1 - High scavenger receptor class B type I expression is related to tumor aggressiveness and poor prognosis in breast cancer

AU - Yuan, Baoying

AU - Wu, Changshun

AU - Wang, Xingwen

AU - Wang, Dan

AU - Liu, Huiling

AU - Guo, Ling

AU - Li, Xiang An

AU - Han, Junqing

AU - Feng, Hong

N1 - Funding Information: This work was supported by grants from the National Natural Science Foundation of China (No. 81201865 and 81202307), and Shandong Science and Technology Development Planning (No. 2011GSF11843 and 2012G0021822). Publisher Copyright: © 2015, International Society of Oncology and BioMarkers (ISOBM).

PY - 2016/3/1

Y1 - 2016/3/1

N2 - Scavenger receptor class B type I (SR-BI) has been linked to the development and progression of breast cancer. However, its clinical significance in breast cancer remains unclear. Here, we evaluated SR-BI expression in a well-characterized breast cancer tissue microarray by immunohistochemistry. High SR-BI expression was observed in 54 % of all breast cancer cases and was significantly associated with advanced pTNM stage (P = 0.002), larger tumor size (P = 0.023), lymph node metastasis (P = 0.012), and the absence of ER (P = 0.014). The Kaplan–Meier survival analysis revealed that patients with high SR-BI expression had significantly shorter overall survival (OS) (P = 0.004). Moreover, multivariate analysis with adjustment for other prognostic factors confirmed that SR-BI was an independent prognostic factor for patient outcome (P = 0.017). Overall, our study demonstrated that high SR-BI expression was related to conventional parameters indicative of more aggressive tumor type and may serve as a new prognostic marker for poor clinical outcome in human breast cancer.

AB - Scavenger receptor class B type I (SR-BI) has been linked to the development and progression of breast cancer. However, its clinical significance in breast cancer remains unclear. Here, we evaluated SR-BI expression in a well-characterized breast cancer tissue microarray by immunohistochemistry. High SR-BI expression was observed in 54 % of all breast cancer cases and was significantly associated with advanced pTNM stage (P = 0.002), larger tumor size (P = 0.023), lymph node metastasis (P = 0.012), and the absence of ER (P = 0.014). The Kaplan–Meier survival analysis revealed that patients with high SR-BI expression had significantly shorter overall survival (OS) (P = 0.004). Moreover, multivariate analysis with adjustment for other prognostic factors confirmed that SR-BI was an independent prognostic factor for patient outcome (P = 0.017). Overall, our study demonstrated that high SR-BI expression was related to conventional parameters indicative of more aggressive tumor type and may serve as a new prognostic marker for poor clinical outcome in human breast cancer.

KW - Breast cancer

KW - Immunohistochemistry

KW - Prognosis

KW - Scavenger receptor class B type I

UR - http://www.scopus.com/inward/record.url?scp=84944704063&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84944704063&partnerID=8YFLogxK

U2 - 10.1007/s13277-015-4141-4

DO - 10.1007/s13277-015-4141-4

M3 - Article

C2 - 26456958

AN - SCOPUS:84944704063

VL - 37

SP - 3581

EP - 3588

IS - 3

ER -

High scavenger receptor class B type I expression is related to tumor aggressiveness and poor prognosis in breast cancer

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this