High scavenger receptor class B type I expression is related to tumor aggressiveness and poor prognosis in breast cancer

Baoying Yuan, Changshun Wu, Xingwen Wang, Dan Wang, Huiling Liu, Ling Guo, Xiang An Li, Junqing Han, Hong Feng

Research output: Contribution to journalArticlepeer-review

50 Scopus citations

Abstract

Scavenger receptor class B type I (SR-BI) has been linked to the development and progression of breast cancer. However, its clinical significance in breast cancer remains unclear. Here, we evaluated SR-BI expression in a well-characterized breast cancer tissue microarray by immunohistochemistry. High SR-BI expression was observed in 54 % of all breast cancer cases and was significantly associated with advanced pTNM stage (P = 0.002), larger tumor size (P = 0.023), lymph node metastasis (P = 0.012), and the absence of ER (P = 0.014). The Kaplan–Meier survival analysis revealed that patients with high SR-BI expression had significantly shorter overall survival (OS) (P = 0.004). Moreover, multivariate analysis with adjustment for other prognostic factors confirmed that SR-BI was an independent prognostic factor for patient outcome (P = 0.017). Overall, our study demonstrated that high SR-BI expression was related to conventional parameters indicative of more aggressive tumor type and may serve as a new prognostic marker for poor clinical outcome in human breast cancer.

Original languageEnglish
Pages (from-to)3581-3588
Number of pages8
JournalTumor Biology
Volume37
Issue number3
DOIs
StatePublished - Mar 1 2016

Bibliographical note

Publisher Copyright:
© 2015, International Society of Oncology and BioMarkers (ISOBM).

Keywords

  • Breast cancer
  • Immunohistochemistry
  • Prognosis
  • Scavenger receptor class B type I

ASJC Scopus subject areas

  • General Medicine

Fingerprint

Dive into the research topics of 'High scavenger receptor class B type I expression is related to tumor aggressiveness and poor prognosis in breast cancer'. Together they form a unique fingerprint.

Cite this