TY - JOUR
T1 - Higher cytotoxic activity and increased levels of IL‐1β, IL‐6, and TNF‐α in patients undergoing cardiopulmonary bypass
AU - Martí, Francesc
AU - Muñoz, Joan
AU - Peiró, Matilde
AU - Bertran, Esther
AU - Ferrán, Carme
AU - Octavio, Carmen
AU - García, Juan
AU - Rueda, FÈLix
PY - 1995/7
Y1 - 1995/7
N2 - Extracorporeal circulation (EC) by surgical bypass is often associated with a systemic inflammatory response. The purpose of this study was to assess the effect of EC on the serum levels of pro‐inflammatory mediators Interleukin (IL)‐1β, IL‐6, tumor necrosis factor (TNF)‐α, and soluble CD‐23. Peripheral blood lymphocyte subsets and natural killer cell (NK) cytotoxic activity were also analyzed before and after the bypass process. The results from eight patients who underwent cardiac surgery showed a significant increase in the levels of IL‐1β, IL‐6, and TNF‐α, a decrease in CD4+/CD8+ lymphocyte ratio, and an overstimulated NK cytotoxic activity. These changes on serum cytokine levels and cellular immunology parameters could play an important role in the development of adverse effects associated with EC. © 1995 Wiley‐Liss, Inc.
AB - Extracorporeal circulation (EC) by surgical bypass is often associated with a systemic inflammatory response. The purpose of this study was to assess the effect of EC on the serum levels of pro‐inflammatory mediators Interleukin (IL)‐1β, IL‐6, tumor necrosis factor (TNF)‐α, and soluble CD‐23. Peripheral blood lymphocyte subsets and natural killer cell (NK) cytotoxic activity were also analyzed before and after the bypass process. The results from eight patients who underwent cardiac surgery showed a significant increase in the levels of IL‐1β, IL‐6, and TNF‐α, a decrease in CD4+/CD8+ lymphocyte ratio, and an overstimulated NK cytotoxic activity. These changes on serum cytokine levels and cellular immunology parameters could play an important role in the development of adverse effects associated with EC. © 1995 Wiley‐Liss, Inc.
KW - Interleukin‐1
KW - Interleukin‐6
KW - cardiopulmonary bypass
KW - extracorporeal circulation
KW - natural killer
KW - tumor necrosis factor‐α
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U2 - 10.1002/ajh.2830490310
DO - 10.1002/ajh.2830490310
M3 - Article
C2 - 7604816
AN - SCOPUS:0029007180
SN - 0361-8609
VL - 49
SP - 237
EP - 239
JO - American Journal of Hematology
JF - American Journal of Hematology
IS - 3
ER -