Higher cytotoxic activity and increased levels of IL‐1β, IL‐6, and TNF‐α in patients undergoing cardiopulmonary bypass

Francesc Martí, Joan Muñoz, Matilde Peiró, Esther Bertran, Carme Ferrán, Carmen Octavio, Juan García, FÈLix Rueda

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

Extracorporeal circulation (EC) by surgical bypass is often associated with a systemic inflammatory response. The purpose of this study was to assess the effect of EC on the serum levels of pro‐inflammatory mediators Interleukin (IL)‐1β, IL‐6, tumor necrosis factor (TNF)‐α, and soluble CD‐23. Peripheral blood lymphocyte subsets and natural killer cell (NK) cytotoxic activity were also analyzed before and after the bypass process. The results from eight patients who underwent cardiac surgery showed a significant increase in the levels of IL‐1β, IL‐6, and TNF‐α, a decrease in CD4+/CD8+ lymphocyte ratio, and an overstimulated NK cytotoxic activity. These changes on serum cytokine levels and cellular immunology parameters could play an important role in the development of adverse effects associated with EC. © 1995 Wiley‐Liss, Inc.

Original languageEnglish
Pages (from-to)237-239
Number of pages3
JournalAmerican Journal of Hematology
Volume49
Issue number3
DOIs
StatePublished - Jul 1995

Keywords

  • Interleukin‐1
  • Interleukin‐6
  • cardiopulmonary bypass
  • extracorporeal circulation
  • natural killer
  • tumor necrosis factor‐α

ASJC Scopus subject areas

  • Hematology

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