Highly efficient expression of interleukin-2 under the control of rabbit β-globin intron ii gene enhances protective immune responses of porcine reproductive and respiratory syndrome (PRRS) DNA vaccine in pigs

Yijun Du; Yu Lu; Xinglong Wang; Jing Qi; Jiyu Liu; Yue Hu; Feng Li; Jiaqiang Wu; Lihui Guo; Junzhen Liu; Haiying Tao; Wenbo Sun; Lei Chen; Xiaoyan Cong; Sufang Ren; Jianli Shi; Jun Li; Jinbao Wang; Baohua Huang; Renzhong Wan

doi:10.1371/journal.pone.0090326

Highly efficient expression of interleukin-2 under the control of rabbit β-globin intron ii gene enhances protective immune responses of porcine reproductive and respiratory syndrome (PRRS) DNA vaccine in pigs

Yijun Du, Yu Lu, Xinglong Wang, Jing Qi, Jiyu Liu, Yue Hu, Feng Li, Jiaqiang Wu, Lihui Guo, Junzhen Liu, Haiying Tao, Wenbo Sun, Lei Chen, Xiaoyan Cong, Sufang Ren, Jianli Shi, Jun Li, Jinbao Wang, Baohua Huang, Renzhong Wan

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) had caused catastrophic losses in swine industry in China. The current inactivated vaccine provided only limited protection, and the attenuated live vaccine could protect piglets against the HP-PRRSV but there was a possibility that the attenuated virus returned to high virulence. In this study, the eukaryotic expression vector pVAX1

Original language	English
Article number	e90326
Journal	PLoS ONE
Volume	9
Issue number	3
DOIs	https://doi.org/10.1371/journal.pone.0090326
State	Published - Mar 6 2014

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology
General Agricultural and Biological Sciences
General

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10.1371/journal.pone.0090326

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Du, Y., Lu, Y., Wang, X., Qi, J., Liu, J., Hu, Y., Li, F., Wu, J., Guo, L., Liu, J., Tao, H., Sun, W., Chen, L., Cong, X., Ren, S., Shi, J., Li, J., Wang, J., Huang, B., & Wan, R. (2014). Highly efficient expression of interleukin-2 under the control of rabbit β-globin intron ii gene enhances protective immune responses of porcine reproductive and respiratory syndrome (PRRS) DNA vaccine in pigs. PLoS ONE, 9(3), Article e90326. https://doi.org/10.1371/journal.pone.0090326

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abstract = "Highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) had caused catastrophic losses in swine industry in China. The current inactivated vaccine provided only limited protection, and the attenuated live vaccine could protect piglets against the HP-PRRSV but there was a possibility that the attenuated virus returned to high virulence. In this study, the eukaryotic expression vector pVAX1",

author = "Yijun Du and Yu Lu and Xinglong Wang and Jing Qi and Jiyu Liu and Yue Hu and Feng Li and Jiaqiang Wu and Lihui Guo and Junzhen Liu and Haiying Tao and Wenbo Sun and Lei Chen and Xiaoyan Cong and Sufang Ren and Jianli Shi and Jun Li and Jinbao Wang and Baohua Huang and Renzhong Wan",

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Du, Y, Lu, Y, Wang, X, Qi, J, Liu, J, Hu, Y, Li, F, Wu, J, Guo, L, Liu, J, Tao, H, Sun, W, Chen, L, Cong, X, Ren, S, Shi, J, Li, J, Wang, J, Huang, B & Wan, R 2014, 'Highly efficient expression of interleukin-2 under the control of rabbit β-globin intron ii gene enhances protective immune responses of porcine reproductive and respiratory syndrome (PRRS) DNA vaccine in pigs', PLoS ONE, vol. 9, no. 3, e90326. https://doi.org/10.1371/journal.pone.0090326

Highly efficient expression of interleukin-2 under the control of rabbit β-globin intron ii gene enhances protective immune responses of porcine reproductive and respiratory syndrome (PRRS) DNA vaccine in pigs. / Du, Yijun; Lu, Yu; Wang, Xinglong et al.
In: PLoS ONE, Vol. 9, No. 3, e90326, 06.03.2014.

Research output: Contribution to journal › Article › peer-review

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AU - Du, Yijun

AU - Lu, Yu

AU - Wang, Xinglong

AU - Qi, Jing

AU - Liu, Jiyu

AU - Hu, Yue

AU - Li, Feng

AU - Wu, Jiaqiang

AU - Guo, Lihui

AU - Liu, Junzhen

AU - Tao, Haiying

AU - Sun, Wenbo

AU - Chen, Lei

AU - Cong, Xiaoyan

AU - Ren, Sufang

AU - Shi, Jianli

AU - Li, Jun

AU - Wang, Jinbao

AU - Huang, Baohua

AU - Wan, Renzhong

PY - 2014/3/6

Y1 - 2014/3/6

N2 - Highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) had caused catastrophic losses in swine industry in China. The current inactivated vaccine provided only limited protection, and the attenuated live vaccine could protect piglets against the HP-PRRSV but there was a possibility that the attenuated virus returned to high virulence. In this study, the eukaryotic expression vector pVAX1

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Highly efficient expression of interleukin-2 under the control of rabbit β-globin intron ii gene enhances protective immune responses of porcine reproductive and respiratory syndrome (PRRS) DNA vaccine in pigs

Abstract

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