TY - JOUR
T1 - Hippocampal aging in rats
T2 - A morphometric study of multiple variables in semithin sections
AU - Landfield, P. W.
AU - Braun, L. D.
AU - Pitler, T. A.
AU - Lindsey, J. D.
AU - Lynch, G.
PY - 1981
Y1 - 1981
N2 - Quantitative analyses of pyramidal cells, astrocytes, dark glia (microglia and dark oligodendrocytes), lipofuscin accumulation and astrocyte reactivity were carried out in semithin sections from field CA3 of the hippocampus of rats in 3 age groups (4-7 mo., 13-15 mo., 25-28 mo.). A decrease in neuronal density (∼25%) and an increase in dark glia were found in the oldest group. The astrocyte population was stable with age. Lipofuscin increased by 13-15 mo. and increased further by 25-28 mo. Qualitative examples of several kinds of glial reactivity are also described. Our observations indicate that hippocampal changes in aging rats exhibit some similarities to brain changes reported in other mammalian species, and also illustrate the value of semithin sections for examining multiple neuromorphologic correlates of brain aging.
AB - Quantitative analyses of pyramidal cells, astrocytes, dark glia (microglia and dark oligodendrocytes), lipofuscin accumulation and astrocyte reactivity were carried out in semithin sections from field CA3 of the hippocampus of rats in 3 age groups (4-7 mo., 13-15 mo., 25-28 mo.). A decrease in neuronal density (∼25%) and an increase in dark glia were found in the oldest group. The astrocyte population was stable with age. Lipofuscin increased by 13-15 mo. and increased further by 25-28 mo. Qualitative examples of several kinds of glial reactivity are also described. Our observations indicate that hippocampal changes in aging rats exhibit some similarities to brain changes reported in other mammalian species, and also illustrate the value of semithin sections for examining multiple neuromorphologic correlates of brain aging.
KW - Aging
KW - Glial reactivity
KW - Hippocampus
KW - Neuronal density
KW - Rats
KW - Semithin sections
UR - http://www.scopus.com/inward/record.url?scp=0019799551&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0019799551&partnerID=8YFLogxK
U2 - 10.1016/0197-4580(81)90034-8
DO - 10.1016/0197-4580(81)90034-8
M3 - Article
C2 - 7335145
AN - SCOPUS:0019799551
SN - 0197-4580
VL - 2
SP - 265
EP - 275
JO - Neurobiology of Aging
JF - Neurobiology of Aging
IS - 4
ER -