Histone mimics: Digging down under

Yiwei Lin, Binhua P. Zhou

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations


Epigenetic deregulation is intimately associated with the development of human diseases. Intensive studies are currently underway to clarify the mechanism for the sake of achieving ideal diagnostic and therapeutic goals. It has been demonstrated that enzymes with histone-modifying activities can also target non-histone proteins, with the underlying mechanism remaining obscure. In this review, we focus on a novel histone mimicry strategy that may be wildly adapted during the non-histone substrate recognition process. Its potential clinical implications are also discussed.

Original languageEnglish
Pages (from-to)228-233
Number of pages6
JournalFrontiers in Biology
Issue number2
StatePublished - Apr 2013

Bibliographical note

Funding Information:
editing of this manuscript. This work was supported by grants from NIH (RO1CA125454), Susan G Komen Foundation (KG081310), Mary Kay Ash Foundation (to B.P. Zhou) and pre-doctoral fellowship (BC101068) from DoD Breast Cancer Research Program (to Y. Lin).


  • epigenetics
  • histone mimicry

ASJC Scopus subject areas

  • Biotechnology
  • Ecology, Evolution, Behavior and Systematics
  • Ecology
  • Genetics


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