Histones H3 and H4 inhibit protein kinase C specifically

N. Sahyoun; H. LeVine; D. Bronson; R. McConnell; P. Cuatrecasas

doi:10.1016/S0006-291X(83)80038-2

Histones H3 and H4 inhibit protein kinase C specifically

N. Sahyoun, H. LeVine, D. Bronson, R. McConnell, P. Cuatrecasas

Molecular and Cellular Biochemistry

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Abstract

The lysine-rich histone H1 is a preferred substrate for the Ca²⁺-phospholipid-dependent protein kinase (protein kinase C). Histones H3 and H4 are poor substrates but potent inhibitors of the enzyme. The inhibitory effect of H3 and H4 seems to result mainly from a decreased sensitivity of protein kinase C to stimulation by phosphatidylserine (PS). These observations suggest that site-specific phosphorylation of one histone type can be regulated by other histones.

Original language	English
Pages (from-to)	1027-1032
Number of pages	6
Journal	Biochemical and Biophysical Research Communications
Volume	115
Issue number	3
DOIs	https://doi.org/10.1016/S0006-291X(83)80038-2
State	Published - Sep 30 1983

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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title = "Histones H3 and H4 inhibit protein kinase C specifically",

abstract = "The lysine-rich histone H1 is a preferred substrate for the Ca2+-phospholipid-dependent protein kinase (protein kinase C). Histones H3 and H4 are poor substrates but potent inhibitors of the enzyme. The inhibitory effect of H3 and H4 seems to result mainly from a decreased sensitivity of protein kinase C to stimulation by phosphatidylserine (PS). These observations suggest that site-specific phosphorylation of one histone type can be regulated by other histones.",

author = "N. Sahyoun and H. LeVine and D. Bronson and R. McConnell and P. Cuatrecasas",

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T1 - Histones H3 and H4 inhibit protein kinase C specifically

AU - Sahyoun, N.

AU - LeVine, H.

AU - Bronson, D.

AU - McConnell, R.

AU - Cuatrecasas, P.

PY - 1983/9/30

Y1 - 1983/9/30

N2 - The lysine-rich histone H1 is a preferred substrate for the Ca2+-phospholipid-dependent protein kinase (protein kinase C). Histones H3 and H4 are poor substrates but potent inhibitors of the enzyme. The inhibitory effect of H3 and H4 seems to result mainly from a decreased sensitivity of protein kinase C to stimulation by phosphatidylserine (PS). These observations suggest that site-specific phosphorylation of one histone type can be regulated by other histones.

AB - The lysine-rich histone H1 is a preferred substrate for the Ca2+-phospholipid-dependent protein kinase (protein kinase C). Histones H3 and H4 are poor substrates but potent inhibitors of the enzyme. The inhibitory effect of H3 and H4 seems to result mainly from a decreased sensitivity of protein kinase C to stimulation by phosphatidylserine (PS). These observations suggest that site-specific phosphorylation of one histone type can be regulated by other histones.

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JF - Biochemical and Biophysical Research Communications

IS - 3

ER -

Histones H3 and H4 inhibit protein kinase C specifically

Abstract

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