Histones H3 and H4 inhibit protein kinase C specifically

N. Sahyoun, H. LeVine, D. Bronson, R. McConnell, P. Cuatrecasas

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


The lysine-rich histone H1 is a preferred substrate for the Ca2+-phospholipid-dependent protein kinase (protein kinase C). Histones H3 and H4 are poor substrates but potent inhibitors of the enzyme. The inhibitory effect of H3 and H4 seems to result mainly from a decreased sensitivity of protein kinase C to stimulation by phosphatidylserine (PS). These observations suggest that site-specific phosphorylation of one histone type can be regulated by other histones.

Original languageEnglish
Pages (from-to)1027-1032
Number of pages6
JournalBiochemical and Biophysical Research Communications
Issue number3
StatePublished - Sep 30 1983

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology


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