HIV-dementia, Tat-induced oxidative stress, and antioxidant therapeutic considerations

Chava B. Pocernich, Rukhsana Sultana, Hafiz Mohmmad-Abdul, Avindra Nath, D. Allan Butterfield

Research output: Contribution to journalReview articlepeer-review

99 Scopus citations


Oxidative stress is thought to play a role in the onset of dementia. HIV-dementia has recently been demonstrated to be associated with oxidative stress as indexed by increased protein and lipid peroxidation in the brain and cerebrospinal fluid compared to HIV non-demented patients. The HIV protein Tat induces neurotoxicity, and, more recently, Tat was found to induce oxidative stress directly and indirectly. The role of Tat in HIV-dementia and possible therapeutic strategies involving endogenous and exogenous antioxidants are discussed.

Original languageEnglish
Pages (from-to)14-26
Number of pages13
JournalBrain Research Reviews
Issue number1
StatePublished - Dec 1 2005

Bibliographical note

Funding Information:
This work was supported in part by grants from NIH (MH64409; AG-10836; AG-05119) to D.A.B. and (RO1 NS39253; P20 RR15592) to A.N.


  • Antioxidant
  • HIV-dementia
  • Oxidative stress
  • Tat

ASJC Scopus subject areas

  • General Neuroscience
  • Clinical Neurology


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