Oxidative stress is thought to play a role in the onset of dementia. HIV-dementia has recently been demonstrated to be associated with oxidative stress as indexed by increased protein and lipid peroxidation in the brain and cerebrospinal fluid compared to HIV non-demented patients. The HIV protein Tat induces neurotoxicity, and, more recently, Tat was found to induce oxidative stress directly and indirectly. The role of Tat in HIV-dementia and possible therapeutic strategies involving endogenous and exogenous antioxidants are discussed.
|Number of pages||13|
|Journal||Brain Research Reviews|
|State||Published - Dec 1 2005|
Bibliographical noteFunding Information:
This work was supported in part by grants from NIH (MH64409; AG-10836; AG-05119) to D.A.B. and (RO1 NS39253; P20 RR15592) to A.N.
- Oxidative stress
ASJC Scopus subject areas
- Neuroscience (all)
- Clinical Neurology