HIV, inflammation, and calcium in atherosclerosis

Sadeep Shrestha, Marguerite R. Irvin, Carl Grunfeld, Donna K. Arnett

Research output: Contribution to journalReview articlepeer-review

40 Scopus citations

Abstract

Atherosclerosis is consistently higher among the HIV-positive patients, with or without treatment, than among the HIV-negative population. Risk factors linked to atherosclerotic cardiovascular disease in HIV infection are both traditional and HIV specific although the underlying mechanisms are not fully delineated. Three key sequential biological processes are postulated to accelerate progression of atherosclerosis in the context of HIV: (1) inflammation, (2) transformation of monocytes to macrophages and then foam cells, and (3) apoptosis of foam cells leading to plaque development through Ca-dependent endoplasmic reticulum stress. These proatherogenic mechanisms are further affected when HIV interacts with the genes involved in various phases within this network.

Original languageEnglish
Pages (from-to)244-250
Number of pages7
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Volume34
Issue number2
DOIs
StatePublished - Feb 2014

Keywords

  • HIV
  • atherosclerosis
  • calcium
  • endoplasmic reticulum stress
  • inflammation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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