TY - JOUR
T1 - HIV protease inhibitors alter innate immune response signaling to double-stranded RNA in oral epithelial cells
T2 - Implications for immune reconstitution inflammatory syndrome?
AU - Danaher, Robert J.
AU - Kaetzel, Charlotte S.
AU - Greenberg, Richard N.
AU - Wang, Chunmei
AU - Bruno, Maria E.C.
AU - Miller, Craig S.
PY - 2010/10/23
Y1 - 2010/10/23
N2 - In this investigation, several HIV protease inhibitors altered the virally associated, double-stranded RNA (dsRNA)-stimulated, innate immune response. Lopinavir, the most potent inducer of interleukin (IL)-8 expression, also inhibited dsRNA-induced monocyte chemotactic protein 1 expression. Further analyses demonstrated that nuclear factor-kB is required for lopinavir's induction of IL-8. These findings demonstrate that protease inhibitors, such as lopinavir, differentially dysregulate innate immune signaling in a manner that could affect immune (reconstitution) inflammatory responses in oral epithelium.
AB - In this investigation, several HIV protease inhibitors altered the virally associated, double-stranded RNA (dsRNA)-stimulated, innate immune response. Lopinavir, the most potent inducer of interleukin (IL)-8 expression, also inhibited dsRNA-induced monocyte chemotactic protein 1 expression. Further analyses demonstrated that nuclear factor-kB is required for lopinavir's induction of IL-8. These findings demonstrate that protease inhibitors, such as lopinavir, differentially dysregulate innate immune signaling in a manner that could affect immune (reconstitution) inflammatory responses in oral epithelium.
UR - http://www.scopus.com/inward/record.url?scp=78549253453&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=78549253453&partnerID=8YFLogxK
U2 - 10.1097/QAD.0b013e32833f4022
DO - 10.1097/QAD.0b013e32833f4022
M3 - Article
C2 - 20841991
AN - SCOPUS:78549253453
SN - 0269-9370
VL - 24
SP - 2587
EP - 2590
JO - AIDS
JF - AIDS
IS - 16
ER -
