TY - JOUR
T1 - HIV, Tuberculosis, and Otogenic Intracranial Sepsis
T2 - A Devastating Disease with a Subtle Presentation
AU - Yakobi, Akhona
AU - Porterfield, James Zachary
AU - Toman, Julia
AU - Spock, Todd
AU - Kapil, Narain
AU - De Meyer, Jenine
AU - Kejner, Alex
AU - Rea, Peter
AU - Gleeson, Michael
AU - Enicker, Basil
AU - Michaelides, Elias
AU - Saman, Yougan
N1 - Publisher Copyright:
© 2019 Lippincott Williams and Wilkins. All rights reserved.
PY - 2019/8/1
Y1 - 2019/8/1
N2 - Objectives:To undertake a large-scale review of otogenic intracranial sepsis in an area of highly prevalent HIV and tuberculosis (TB) to re-examine and inform early diagnosis and treatment efforts.Methods:Seventy-seven consecutive cases of otogenic intracranial sepsis in KwaZulu-Natal, South Africa were reviewed for demographics, presentation, imaging, HIV status, culture results, and outcomes.Results:The most common intracranial complications were intracranial abscess (46.8%), hydrocephalus (31.2%), subdural empyema (28.6%), and epidural empyema (26.0%). Ear discharge (87.0%), postauricular abscess (29.9%), and hearing loss (29.9%) were notable presenting symptoms. Overall mortality was 15.6%. Of the 45.5% of patients with HIV testing, 54.2% were HIV+, Mortality among HIV+ patients was 15.8% but only 6.3% in HIV- patients (p=0.61, OR=2.8). Eight patients (10.4%) had culture or histological evidence of TB infection.Conclusions:Otogenic intracranial complications continue to present late and are associated with significant mortality and morbidity, despite advances in diagnostic and treatment modalities. This study represents one of the largest case-series in the literature, and the first to specifically evaluate the effects of HIV and TB infection.Patient presentation and severity of illness varied; however, a majority of patients presented with ear discharge and no focal neurological signs. An effect size for higher mortality among HIV+ patients compared with HIV- patients was noted but was not significant. Tuberculosis infection was prevalent compared with previous studies.This study reinforces the need for enhanced screening and early treatment of ear disease to minimize associated mortality and morbidity, particularly in immunocompromised patients.
AB - Objectives:To undertake a large-scale review of otogenic intracranial sepsis in an area of highly prevalent HIV and tuberculosis (TB) to re-examine and inform early diagnosis and treatment efforts.Methods:Seventy-seven consecutive cases of otogenic intracranial sepsis in KwaZulu-Natal, South Africa were reviewed for demographics, presentation, imaging, HIV status, culture results, and outcomes.Results:The most common intracranial complications were intracranial abscess (46.8%), hydrocephalus (31.2%), subdural empyema (28.6%), and epidural empyema (26.0%). Ear discharge (87.0%), postauricular abscess (29.9%), and hearing loss (29.9%) were notable presenting symptoms. Overall mortality was 15.6%. Of the 45.5% of patients with HIV testing, 54.2% were HIV+, Mortality among HIV+ patients was 15.8% but only 6.3% in HIV- patients (p=0.61, OR=2.8). Eight patients (10.4%) had culture or histological evidence of TB infection.Conclusions:Otogenic intracranial complications continue to present late and are associated with significant mortality and morbidity, despite advances in diagnostic and treatment modalities. This study represents one of the largest case-series in the literature, and the first to specifically evaluate the effects of HIV and TB infection.Patient presentation and severity of illness varied; however, a majority of patients presented with ear discharge and no focal neurological signs. An effect size for higher mortality among HIV+ patients compared with HIV- patients was noted but was not significant. Tuberculosis infection was prevalent compared with previous studies.This study reinforces the need for enhanced screening and early treatment of ear disease to minimize associated mortality and morbidity, particularly in immunocompromised patients.
KW - Brain abscess
KW - Chronic suppurative otitis media
KW - HIV
KW - Otitis media
KW - Otogenic intracranial sepsis
KW - South Africa
KW - Tuberculosis
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U2 - 10.1097/MAO.0000000000002290
DO - 10.1097/MAO.0000000000002290
M3 - Article
C2 - 31295202
AN - SCOPUS:85069776223
SN - 1531-7129
VL - 40
SP - E704-E712
JO - Otology and Neurotology
JF - Otology and Neurotology
IS - 7
ER -