Home heparin therapy used in a pregnant patient with a mechanical heart valve prosthesis

Victor A. Ferraris, Robert R. Klingman, Linda Dunn, Steven Fein, Marla Eglowstein, Renee Samelson

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


The optimal anticoagulation therapy for pregnant patients with a mechanical valve prosthesis is uncertain, but teratogenic effects and the high incidence of fetal loss associated with dicumarol derivatives limit the use of these agents as anticoagulants in this setting. A patient with a mechanical valve prosthesis, in the first trimester of pregnancy, stopped taking her warfarin because of personal fears about teratogenicity. Prosthetic valve thrombosis developed, and she required redo mitral valve replacement. Another mechanical prosthesis was inserted without maternal or fetal injury. The patient was maintained on continuous home, intravenous, high-dose heparin therapy for the remainder of her pregnancy. This therapy resulted in a successful pregnancy and delivery without valve thrombosis, hemorrhagic events, or maternal or fetal compromise.

Original languageEnglish
Pages (from-to)1168-1170
Number of pages3
JournalAnnals of Thoracic Surgery
Issue number4
StatePublished - Oct 1994

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine


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