Homeostasis of Lipid Metabolism in Disorders of the Brain

Jennifer L. Johnson; Lance A. Johnson

doi:10.1016/B978-0-12-819641-0.00146-8

Homeostasis of Lipid Metabolism in Disorders of the Brain

Jennifer L. Johnson, Lance A. Johnson

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

2 Scopus citations

Abstract

Making up half of the brain's dry weight, lipids are essential for the brain's structure and function. Their importance in the brain is highlighted by the number of inherited and multifactorial neurological disorders that involve dysregulated lipid metabolism. However, it is unknown if lipids contribute to these disorders through direct or indirect mechanisms. In the present chapter, we highlight the function of lipids in the brain, the effects of their perturbations, and their critical role in several different neurological disorders.

Original language	English
Title of host publication	Encyclopedia of Behavioral Neuroscience
Subtitle of host publication	Volumes 1-3, Second edition
Pages	V1-372-V1-382
Volume	1-3
ISBN (Electronic)	9780128196410
DOIs	https://doi.org/10.1016/B978-0-12-819641-0.00146-8
State	Published - Jan 1 2021

Bibliographical note

Publisher Copyright:
© 2021 Elsevier Ltd. All rights reserved.

Keywords

Cholesterol
Glycerophospholipids
Lipid metabolism
Lysosomal storage disorders
Membrane microdomains
Neurodegenerative diseases
Neurological disorders
Neuropsychiatric disorders
Polyunsaturated fatty acids
Sphingolipids

ASJC Scopus subject areas

General Medicine
General Neuroscience

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AB - Making up half of the brain's dry weight, lipids are essential for the brain's structure and function. Their importance in the brain is highlighted by the number of inherited and multifactorial neurological disorders that involve dysregulated lipid metabolism. However, it is unknown if lipids contribute to these disorders through direct or indirect mechanisms. In the present chapter, we highlight the function of lipids in the brain, the effects of their perturbations, and their critical role in several different neurological disorders.

KW - Cholesterol

KW - Glycerophospholipids

KW - Lipid metabolism

KW - Lysosomal storage disorders

KW - Membrane microdomains

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KW - Neurological disorders

KW - Neuropsychiatric disorders

KW - Polyunsaturated fatty acids

KW - Sphingolipids

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M3 - Chapter

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BT - Encyclopedia of Behavioral Neuroscience

ER -

Homeostasis of Lipid Metabolism in Disorders of the Brain

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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