Host factors with regulatory roles in tombusvirus replication

Peter D. Nagy, Daniel Barajas, Judit Pogany

Research output: Contribution to journalReview articlepeer-review

57 Scopus citations


Similar to animal viruses, the abundant plant positive-strand RNA viruses replicate in infected cells by exploiting the vast resources of the host. This review focuses on virus-host interactions during tombusvirus replication. The multifunctional tombusvirus p33 replication protein not only interacts with itself, the viral p92pol polymerase, and viral RNA, but also with approximately 100 cellular proteins and subcellular membranes. Several negative regulatory host proteins, such as cyclophilins and WW motif containing proteins, also bind to p33 and interfere with p33's functions. To explain how p33 can perform multiple functions, we propose that a variety of interactions involving p33 result in the commitment of p33 molecules to specific tasks. This facilitates tight spatial and temporal organization of viral replication in infected cells.

Original languageEnglish
Pages (from-to)691-698
Number of pages8
JournalCurrent Opinion in Virology
Issue number6
StatePublished - Dec 2012

Bibliographical note

Funding Information:
We thank members of our laboratory for valuable discussions on the areas of this review. We apologize to those colleagues whose work could not be included because of space restrictions. This work was supported by the National Institute of Allergy and Infectious Diseases (NIH-NIAID AI05767001A1 ) and by the University of Kentucky , awarded to PDN.

ASJC Scopus subject areas

  • Virology


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