Host factors with regulatory roles in tombusvirus replication

Peter D. Nagy; Daniel Barajas; Judit Pogany

doi:10.1016/j.coviro.2012.10.004

Host factors with regulatory roles in tombusvirus replication

Peter D. Nagy, Daniel Barajas, Judit Pogany

Plant Pathology

Research output: Contribution to journal › Review article › peer-review

61 Scopus citations

Abstract

Similar to animal viruses, the abundant plant positive-strand RNA viruses replicate in infected cells by exploiting the vast resources of the host. This review focuses on virus-host interactions during tombusvirus replication. The multifunctional tombusvirus p33 replication protein not only interacts with itself, the viral p92^pol polymerase, and viral RNA, but also with approximately 100 cellular proteins and subcellular membranes. Several negative regulatory host proteins, such as cyclophilins and WW motif containing proteins, also bind to p33 and interfere with p33's functions. To explain how p33 can perform multiple functions, we propose that a variety of interactions involving p33 result in the commitment of p33 molecules to specific tasks. This facilitates tight spatial and temporal organization of viral replication in infected cells.

Original language	English
Pages (from-to)	691-698
Number of pages	8
Journal	Current Opinion in Virology
Volume	2
Issue number	6
DOIs	https://doi.org/10.1016/j.coviro.2012.10.004
State	Published - Dec 2012

Bibliographical note

Funding Information:
We thank members of our laboratory for valuable discussions on the areas of this review. We apologize to those colleagues whose work could not be included because of space restrictions. This work was supported by the National Institute of Allergy and Infectious Diseases (NIH-NIAID AI05767001A1 ) and by the University of Kentucky , awarded to PDN.

Funding

We thank members of our laboratory for valuable discussions on the areas of this review. We apologize to those colleagues whose work could not be included because of space restrictions. This work was supported by the National Institute of Allergy and Infectious Diseases (NIH-NIAID AI05767001A1 ) and by the University of Kentucky , awarded to PDN.

Funders	Funder number
NIH-NIAID	AI05767001A1
National Institutes of Health (NIH)	F32AI005767
National Institute of Allergy and Infectious Diseases
University of Kentucky

ASJC Scopus subject areas

Virology

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10.1016/j.coviro.2012.10.004

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title = "Host factors with regulatory roles in tombusvirus replication",

abstract = "Similar to animal viruses, the abundant plant positive-strand RNA viruses replicate in infected cells by exploiting the vast resources of the host. This review focuses on virus-host interactions during tombusvirus replication. The multifunctional tombusvirus p33 replication protein not only interacts with itself, the viral p92pol polymerase, and viral RNA, but also with approximately 100 cellular proteins and subcellular membranes. Several negative regulatory host proteins, such as cyclophilins and WW motif containing proteins, also bind to p33 and interfere with p33's functions. To explain how p33 can perform multiple functions, we propose that a variety of interactions involving p33 result in the commitment of p33 molecules to specific tasks. This facilitates tight spatial and temporal organization of viral replication in infected cells.",

author = "Nagy, {Peter D.} and Daniel Barajas and Judit Pogany",

note = "Funding Information: We thank members of our laboratory for valuable discussions on the areas of this review. We apologize to those colleagues whose work could not be included because of space restrictions. This work was supported by the National Institute of Allergy and Infectious Diseases (NIH-NIAID AI05767001A1 ) and by the University of Kentucky , awarded to PDN. ",

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doi = "10.1016/j.coviro.2012.10.004",

language = "English",

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AU - Nagy, Peter D.

AU - Barajas, Daniel

AU - Pogany, Judit

N1 - Funding Information: We thank members of our laboratory for valuable discussions on the areas of this review. We apologize to those colleagues whose work could not be included because of space restrictions. This work was supported by the National Institute of Allergy and Infectious Diseases (NIH-NIAID AI05767001A1 ) and by the University of Kentucky , awarded to PDN.

PY - 2012/12

Y1 - 2012/12

N2 - Similar to animal viruses, the abundant plant positive-strand RNA viruses replicate in infected cells by exploiting the vast resources of the host. This review focuses on virus-host interactions during tombusvirus replication. The multifunctional tombusvirus p33 replication protein not only interacts with itself, the viral p92pol polymerase, and viral RNA, but also with approximately 100 cellular proteins and subcellular membranes. Several negative regulatory host proteins, such as cyclophilins and WW motif containing proteins, also bind to p33 and interfere with p33's functions. To explain how p33 can perform multiple functions, we propose that a variety of interactions involving p33 result in the commitment of p33 molecules to specific tasks. This facilitates tight spatial and temporal organization of viral replication in infected cells.

AB - Similar to animal viruses, the abundant plant positive-strand RNA viruses replicate in infected cells by exploiting the vast resources of the host. This review focuses on virus-host interactions during tombusvirus replication. The multifunctional tombusvirus p33 replication protein not only interacts with itself, the viral p92pol polymerase, and viral RNA, but also with approximately 100 cellular proteins and subcellular membranes. Several negative regulatory host proteins, such as cyclophilins and WW motif containing proteins, also bind to p33 and interfere with p33's functions. To explain how p33 can perform multiple functions, we propose that a variety of interactions involving p33 result in the commitment of p33 molecules to specific tasks. This facilitates tight spatial and temporal organization of viral replication in infected cells.

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JO - Current Opinion in Virology

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Host factors with regulatory roles in tombusvirus replication

Abstract

Bibliographical note

Funding

ASJC Scopus subject areas

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