Hostility, social support, and carotid artery atherosclerosis in The National Heart, Lung, and Blood Institute Family Heart Study

Sarah S. Knox, Avril Adelman, R. Curtis Ellison, Donna K. Arnett, Kimberly Siegmund, Gerdi Weidner, Michael A. Province

Research output: Contribution to journalArticlepeer-review

64 Scopus citations


This cross-sectional study investigates the association of hostility and social support (measured by standardized instruments) to carotid artery atherosclerosis in men and women with a high familial risk for coronary heart disease (CHD) and those with low to medium risk. The hypothesis was that high hostility and low social support would have a stronger association in subjects with a familial predisposition to CHD. There were 535 low- to medium-risk women, 491 low- to medium-risk men, 1,950 high-risk women, and 1,667 high-risk men in the study. The extent of carotid artery atherosclerosis was assessed by B-mode ultrasound imaging. A lesion was defined as an intimal-medial far wall thickness of 1 mm in the common, internal, or carotid bifurcation, or identification of plaque at any site. Odds ratios and their 95% confidence intervals were calculated using generalized estimating equations (GEE) for logistic regression. Family was specified as the clustering variable, and robust SEEs were obtained that account for dependence of the data within families. After controlling for age, education, body mass index, ever having smoked, ever drinking >5 drinks a day, and metabolic index, hostility was significantly associated with increased odds of carotid lesions in only high-risk women. High-risk women showed a significantly reduced odds of carotid lesions with high social support, but the extent of this protection was reduced when age and education were included in the equation. A combination of high hostility and low social support was associated with higher odds than hostility alone in both high-risk men and women. These results suggest that women with a high familial predisposition for CHD may be more vulnerable to cardiovascular influences from hostility and social support than high-risk men or men and women with low to medium risk. Copyright (C) 2000 Excerpta Medica Inc.

Original languageEnglish
Pages (from-to)1086-1089
Number of pages4
JournalAmerican Journal of Cardiology
Issue number10
StatePublished - Nov 15 2000

Bibliographical note

Funding Information:
This study was supported by contracts N01-HC-25104 through 25109 from the National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland. Manuscript received February 17, 2000; revised manuscript received and accepted May 19, 2000.

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


Dive into the research topics of 'Hostility, social support, and carotid artery atherosclerosis in The National Heart, Lung, and Blood Institute Family Heart Study'. Together they form a unique fingerprint.

Cite this