Human papillomavirus genotype prevalence in invasive penile cancers from a registry-based united states population

Brenda Y. Hernandez; Marc T. Goodman; Elizabeth R. Unger; Martin Steinau; Amy Powers; Charles F. Lynch; Wendy Cozen; Maria Sibug Saber; Edward S. Peters; Edward J. Wilkinson; Glenn Copeland; Claudia Hopenhayn; Youjie Huang; Meg Watson; Sean F. Altekruse; Christopher Lyu; Mona Saraiya; Mariela Z. Scarbrough; Trevor Thompson; Deblina Datta; Susan Hariri; Bruce Ellis; Natalie Madero; Emily Reid; Donna Little; April Greek; Dale Rhoda; Susan Brossoie; Katherine Gideon; Linda Delma Gieseke; Stephanie Ashcraft; Jill MacKinnon; Carlos Alvarez; Edward Wilkinson; Martha Campbell-Thompson; Amy Wright; Kelley Durden; Brenda Hernandez; Marc Goodman; Hugh Luk; David Horio; Shoji Ikeda; Michael Green; Catherine Grafel-Anderson; Rayna Weise; Freda Selk; Dan Olson; Thomas Tucker; Amy Christian; Edward Peters; Lauren Cole; Tara Ruhlen; Joe House; Myles G. Cockburn; Andre Kim; Lana Ashley; Jetty Alverson; Michelle Hulbert; Won Silva; Samuel Hirsch

doi:10.3389/fonc.2014.00009

Human papillomavirus genotype prevalence in invasive penile cancers from a registry-based united states population

Brenda Y. Hernandez, Marc T. Goodman, Elizabeth R. Unger, Martin Steinau, Amy Powers, Charles F. Lynch, Wendy Cozen, Maria Sibug Saber, Edward S. Peters, Edward J. Wilkinson, Glenn Copeland, Claudia Hopenhayn, Youjie Huang, Meg Watson, Sean F. Altekruse, Christopher Lyu, Mona Saraiya, Mariela Z. Scarbrough, Trevor Thompson, Deblina DattaSusan Hariri, Bruce Ellis, Natalie Madero, Emily Reid, Donna Little, April Greek, Dale Rhoda, Susan Brossoie, Katherine Gideon, Linda Delma Gieseke, Stephanie Ashcraft, Jill MacKinnon, Carlos Alvarez, Edward Wilkinson, Martha Campbell-Thompson, Amy Wright, Kelley Durden, Brenda Hernandez, Marc Goodman, Hugh Luk, David Horio, Shoji Ikeda, Michael Green, Catherine Grafel-Anderson, Rayna Weise, Freda Selk, Dan Olson, Thomas Tucker, Amy Christian, Edward Peters, Lauren Cole, Tara Ruhlen, Joe House, Myles G. Cockburn, Andre Kim, Lana Ashley, Jetty Alverson, Michelle Hulbert, Won Silva, Samuel Hirsch

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

Abstract

Background: Human papillomavirus (HPV) is estimated to play an etiologic role in 40-50% of penile cancers worldwide. Estimates of HPV prevalence in U.S. penile cancer cases are limited. Methods: HPV DNA was evaluated in tumor tissue from 79 invasive penile cancer patients diagnosed in 1998-2005 within the catchment areas of seven U.S. cancer registries. HPV was genotyped using PCR-based Linear Array and INNO-LiPA assays and compared by demographic, clinical, and pathologic characteristics and survival. Histological classification was also obtained by independent pathology review. Results: HPV DNA was present in 50 of 79 (63%) of invasive penile cancer cases. Sixteen viral genotypes were detected. HPV 16, found in 46% (36/79) of all cases (72% of HPV-positive cases) was the most prevalent genotype followed equally by HPV 18, 33, and 45, each of which comprised 5% of all cases. Multiple genotypes were detected in 18% of viral positive cases. HPV prevalence did not significantly vary by age, race/ethnicity, population size of geographic region, cancer stage, histology, grade, penile subsite, or prior cancer history. Penile cases diagnosed in more recent years were more likely to be HPV-positive. Overall survival did not significantly vary by HPV status. Conclusion: The relatively high prevalence of HPV in our study population provides limited evidence of a more prominent and, possibly, increasing role of infection in penile carcinogenesis in the U.S. compared to other parts of the world.

Original language	English
Article number	Article 9
Journal	Frontiers in Oncology
Volume	4 FEB
DOIs	https://doi.org/10.3389/fonc.2014.00009
State	Published - 2014

Keywords

HPV
Human papillomavirus
Penile cancer
Prevalence
United states

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3389/fonc.2014.00009

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Hernandez, B. Y., Goodman, M. T., Unger, E. R., Steinau, M., Powers, A., Lynch, C. F., Cozen, W., Saber, M. S., Peters, E. S., Wilkinson, E. J., Copeland, G., Hopenhayn, C., Huang, Y., Watson, M., Altekruse, S. F., Lyu, C., Saraiya, M., Scarbrough, M. Z., Thompson, T., ... Hirsch, S. (2014). Human papillomavirus genotype prevalence in invasive penile cancers from a registry-based united states population. Frontiers in Oncology, 4 FEB, Article Article 9. https://doi.org/10.3389/fonc.2014.00009

@article{af8e9d30e8b3427e82d74f99e0598478,

title = "Human papillomavirus genotype prevalence in invasive penile cancers from a registry-based united states population",

abstract = "Background: Human papillomavirus (HPV) is estimated to play an etiologic role in 40-50% of penile cancers worldwide. Estimates of HPV prevalence in U.S. penile cancer cases are limited. Methods: HPV DNA was evaluated in tumor tissue from 79 invasive penile cancer patients diagnosed in 1998-2005 within the catchment areas of seven U.S. cancer registries. HPV was genotyped using PCR-based Linear Array and INNO-LiPA assays and compared by demographic, clinical, and pathologic characteristics and survival. Histological classification was also obtained by independent pathology review. Results: HPV DNA was present in 50 of 79 (63%) of invasive penile cancer cases. Sixteen viral genotypes were detected. HPV 16, found in 46% (36/79) of all cases (72% of HPV-positive cases) was the most prevalent genotype followed equally by HPV 18, 33, and 45, each of which comprised 5% of all cases. Multiple genotypes were detected in 18% of viral positive cases. HPV prevalence did not significantly vary by age, race/ethnicity, population size of geographic region, cancer stage, histology, grade, penile subsite, or prior cancer history. Penile cases diagnosed in more recent years were more likely to be HPV-positive. Overall survival did not significantly vary by HPV status. Conclusion: The relatively high prevalence of HPV in our study population provides limited evidence of a more prominent and, possibly, increasing role of infection in penile carcinogenesis in the U.S. compared to other parts of the world.",

keywords = "HPV, Human papillomavirus, Penile cancer, Prevalence, United states",

author = "Hernandez, {Brenda Y.} and Goodman, {Marc T.} and Unger, {Elizabeth R.} and Martin Steinau and Amy Powers and Lynch, {Charles F.} and Wendy Cozen and Saber, {Maria Sibug} and Peters, {Edward S.} and Wilkinson, {Edward J.} and Glenn Copeland and Claudia Hopenhayn and Youjie Huang and Meg Watson and Altekruse, {Sean F.} and Christopher Lyu and Mona Saraiya and Scarbrough, {Mariela Z.} and Trevor Thompson and Deblina Datta and Susan Hariri and Bruce Ellis and Natalie Madero and Emily Reid and Donna Little and April Greek and Dale Rhoda and Susan Brossoie and Katherine Gideon and Gieseke, {Linda Delma} and Stephanie Ashcraft and Jill MacKinnon and Carlos Alvarez and Edward Wilkinson and Martha Campbell-Thompson and Amy Wright and Kelley Durden and Brenda Hernandez and Marc Goodman and Hugh Luk and David Horio and Shoji Ikeda and Michael Green and Catherine Grafel-Anderson and Rayna Weise and Freda Selk and Dan Olson and Thomas Tucker and Amy Christian and Edward Peters and Lauren Cole and Tara Ruhlen and Joe House and Cockburn, {Myles G.} and Andre Kim and Lana Ashley and Jetty Alverson and Michelle Hulbert and Won Silva and Samuel Hirsch",

year = "2014",

doi = "10.3389/fonc.2014.00009",

language = "English",

volume = "4 FEB",

}

Hernandez, BY, Goodman, MT, Unger, ER, Steinau, M, Powers, A, Lynch, CF, Cozen, W, Saber, MS, Peters, ES, Wilkinson, EJ, Copeland, G, Hopenhayn, C, Huang, Y, Watson, M, Altekruse, SF, Lyu, C, Saraiya, M, Scarbrough, MZ, Thompson, T, Datta, D, Hariri, S, Ellis, B, Madero, N, Reid, E, Little, D, Greek, A, Rhoda, D, Brossoie, S, Gideon, K, Gieseke, LD, Ashcraft, S, MacKinnon, J, Alvarez, C, Wilkinson, E, Campbell-Thompson, M, Wright, A, Durden, K, Hernandez, B, Goodman, M, Luk, H, Horio, D, Ikeda, S, Green, M, Grafel-Anderson, C, Weise, R, Selk, F, Olson, D, Tucker, T, Christian, A, Peters, E, Cole, L, Ruhlen, T, House, J, Cockburn, MG, Kim, A, Ashley, L, Alverson, J, Hulbert, M, Silva, W & Hirsch, S 2014, 'Human papillomavirus genotype prevalence in invasive penile cancers from a registry-based united states population', Frontiers in Oncology, vol. 4 FEB, Article 9. https://doi.org/10.3389/fonc.2014.00009

TY - JOUR

T1 - Human papillomavirus genotype prevalence in invasive penile cancers from a registry-based united states population

AU - Hernandez, Brenda Y.

AU - Goodman, Marc T.

AU - Unger, Elizabeth R.

AU - Steinau, Martin

AU - Powers, Amy

AU - Lynch, Charles F.

AU - Cozen, Wendy

AU - Saber, Maria Sibug

AU - Peters, Edward S.

AU - Wilkinson, Edward J.

AU - Copeland, Glenn

AU - Hopenhayn, Claudia

AU - Huang, Youjie

AU - Watson, Meg

AU - Altekruse, Sean F.

AU - Lyu, Christopher

AU - Saraiya, Mona

AU - Scarbrough, Mariela Z.

AU - Thompson, Trevor

AU - Datta, Deblina

AU - Hariri, Susan

AU - Ellis, Bruce

AU - Madero, Natalie

AU - Reid, Emily

AU - Little, Donna

AU - Greek, April

AU - Rhoda, Dale

AU - Brossoie, Susan

AU - Gideon, Katherine

AU - Gieseke, Linda Delma

AU - Ashcraft, Stephanie

AU - MacKinnon, Jill

AU - Alvarez, Carlos

AU - Wilkinson, Edward

AU - Campbell-Thompson, Martha

AU - Wright, Amy

AU - Durden, Kelley

AU - Hernandez, Brenda

AU - Goodman, Marc

AU - Luk, Hugh

AU - Horio, David

AU - Ikeda, Shoji

AU - Green, Michael

AU - Grafel-Anderson, Catherine

AU - Weise, Rayna

AU - Selk, Freda

AU - Olson, Dan

AU - Tucker, Thomas

AU - Christian, Amy

AU - Peters, Edward

AU - Cole, Lauren

AU - Ruhlen, Tara

AU - House, Joe

AU - Cockburn, Myles G.

AU - Kim, Andre

AU - Ashley, Lana

AU - Alverson, Jetty

AU - Hulbert, Michelle

AU - Silva, Won

AU - Hirsch, Samuel

PY - 2014

Y1 - 2014

N2 - Background: Human papillomavirus (HPV) is estimated to play an etiologic role in 40-50% of penile cancers worldwide. Estimates of HPV prevalence in U.S. penile cancer cases are limited. Methods: HPV DNA was evaluated in tumor tissue from 79 invasive penile cancer patients diagnosed in 1998-2005 within the catchment areas of seven U.S. cancer registries. HPV was genotyped using PCR-based Linear Array and INNO-LiPA assays and compared by demographic, clinical, and pathologic characteristics and survival. Histological classification was also obtained by independent pathology review. Results: HPV DNA was present in 50 of 79 (63%) of invasive penile cancer cases. Sixteen viral genotypes were detected. HPV 16, found in 46% (36/79) of all cases (72% of HPV-positive cases) was the most prevalent genotype followed equally by HPV 18, 33, and 45, each of which comprised 5% of all cases. Multiple genotypes were detected in 18% of viral positive cases. HPV prevalence did not significantly vary by age, race/ethnicity, population size of geographic region, cancer stage, histology, grade, penile subsite, or prior cancer history. Penile cases diagnosed in more recent years were more likely to be HPV-positive. Overall survival did not significantly vary by HPV status. Conclusion: The relatively high prevalence of HPV in our study population provides limited evidence of a more prominent and, possibly, increasing role of infection in penile carcinogenesis in the U.S. compared to other parts of the world.

AB - Background: Human papillomavirus (HPV) is estimated to play an etiologic role in 40-50% of penile cancers worldwide. Estimates of HPV prevalence in U.S. penile cancer cases are limited. Methods: HPV DNA was evaluated in tumor tissue from 79 invasive penile cancer patients diagnosed in 1998-2005 within the catchment areas of seven U.S. cancer registries. HPV was genotyped using PCR-based Linear Array and INNO-LiPA assays and compared by demographic, clinical, and pathologic characteristics and survival. Histological classification was also obtained by independent pathology review. Results: HPV DNA was present in 50 of 79 (63%) of invasive penile cancer cases. Sixteen viral genotypes were detected. HPV 16, found in 46% (36/79) of all cases (72% of HPV-positive cases) was the most prevalent genotype followed equally by HPV 18, 33, and 45, each of which comprised 5% of all cases. Multiple genotypes were detected in 18% of viral positive cases. HPV prevalence did not significantly vary by age, race/ethnicity, population size of geographic region, cancer stage, histology, grade, penile subsite, or prior cancer history. Penile cases diagnosed in more recent years were more likely to be HPV-positive. Overall survival did not significantly vary by HPV status. Conclusion: The relatively high prevalence of HPV in our study population provides limited evidence of a more prominent and, possibly, increasing role of infection in penile carcinogenesis in the U.S. compared to other parts of the world.

KW - HPV

KW - Human papillomavirus

KW - Penile cancer

KW - Prevalence

KW - United states

UR - http://www.scopus.com/inward/record.url?scp=84898657999&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84898657999&partnerID=8YFLogxK

U2 - 10.3389/fonc.2014.00009

DO - 10.3389/fonc.2014.00009

M3 - Article

AN - SCOPUS:84898657999

SN - 2234-943X

VL - 4 FEB

JO - Frontiers in Oncology

JF - Frontiers in Oncology

M1 - Article 9

ER -

Human papillomavirus genotype prevalence in invasive penile cancers from a registry-based united states population

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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