Human papillomavirus prevalence in oropharyngeal cancer before vaccine introduction, United States

Martin Steinau, Mona Saraiya, Marc T. Goodman, Edward S. Peters, Meg Watson, Jennifer L. Cleveland, Charles F. Lynch, Edward J. Wilkinson, Brenda Y. Hernandez, Glen Copeland, Maria S. Saber, Claudia Hopenhayn, Youjie Huang, Wendy Cozen, Christopher Lyu, Elizabeth R. Unger, Bruce Ellis, Natalie Madero, Emily Reid, Donna LittleApril Greek, Dale Rhoda, Linda Delma Gieseke, Stephanie Ashcraft, Katherine Gideon, Tara Ruhlen, Mariela Z. Scarbrough, Trevor Thompson, Deblina Datta, Susan Hariri, Lauren Cole, Lana Ashley, Jetty Alverson, Michelle Hulbert, Won Silva, Sean Altekruse, Samuel Hirsch, Martha Campbell-Thompson, Amy Wright, Kelley Durden, Jill MacKinnon, Carlos Alvarez, Hugh Luk, David Horio, Shoji Ikeda, Michael Green, Catherine Grafel-Anderson, Rayna Weise, Freda Selk, Dan Olson, Thomas Tucker, Amy Christian, Susan Brossoie, Joe House, Myles G. Cockburn, Andre Kim

Research output: Contribution to journalArticlepeer-review

81 Scopus citations


We conducted a study to determine prevalence of HPV types in oropharyngeal cancers in the United States and establish a prevaccine baseline for monitoring the impact of vaccination. HPV DNA was extracted from tumor tissue samples from patients in whom cancer was diagnosed during 1995-2005. The samples were obtained from cancer registries and Residual Tissue Repository Program sites in the United States. HPV was detected and typed by using PCR reverse line blot assays. Among 557 invasive oropharyngeal squamous cell carcinomas, 72% were positive for HPV and 62% for vaccine types HPV16 or 18. Prevalence of HPV- 16/18 was lower in women (53%) than in men (66%), and lower in non-Hispanic Black patients (31%) than in other racial/ ethnic groups (68%-80%). Results indicate that vaccines could prevent most oropharyngeal cancers in the United States, but their effect may vary by demographic variables.

Original languageEnglish
Pages (from-to)822-828
Number of pages7
JournalEmerging Infectious Diseases
Issue number5
StatePublished - May 2014

ASJC Scopus subject areas

  • Epidemiology
  • Microbiology (medical)
  • Infectious Diseases


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