Human papillomavirus prevalence in oropharyngeal cancer before vaccine introduction, United States

Martin Steinau; Mona Saraiya; Marc T. Goodman; Edward S. Peters; Meg Watson; Jennifer L. Cleveland; Charles F. Lynch; Edward J. Wilkinson; Brenda Y. Hernandez; Glen Copeland; Maria S. Saber; Claudia Hopenhayn; Youjie Huang; Wendy Cozen; Christopher Lyu; Elizabeth R. Unger; Bruce Ellis; Natalie Madero; Emily Reid; Donna Little; April Greek; Dale Rhoda; Linda Delma Gieseke; Stephanie Ashcraft; Katherine Gideon; Tara Ruhlen; Mariela Z. Scarbrough; Trevor Thompson; Deblina Datta; Susan Hariri; Lauren Cole; Lana Ashley; Jetty Alverson; Michelle Hulbert; Won Silva; Sean Altekruse; Samuel Hirsch; Martha Campbell-Thompson; Amy Wright; Kelley Durden; Jill MacKinnon; Carlos Alvarez; Hugh Luk; David Horio; Shoji Ikeda; Michael Green; Catherine Grafel-Anderson; Rayna Weise; Freda Selk; Dan Olson; Thomas Tucker; Amy Christian; Susan Brossoie; Joe House; Myles G. Cockburn; Andre Kim

doi:10.3201/eid2005.131311

Human papillomavirus prevalence in oropharyngeal cancer before vaccine introduction, United States

Martin Steinau, Mona Saraiya, Marc T. Goodman, Edward S. Peters, Meg Watson, Jennifer L. Cleveland, Charles F. Lynch, Edward J. Wilkinson, Brenda Y. Hernandez, Glen Copeland, Maria S. Saber, Claudia Hopenhayn, Youjie Huang, Wendy Cozen, Christopher Lyu, Elizabeth R. Unger, Bruce Ellis, Natalie Madero, Emily Reid, Donna LittleApril Greek, Dale Rhoda, Linda Delma Gieseke, Stephanie Ashcraft, Katherine Gideon, Tara Ruhlen, Mariela Z. Scarbrough, Trevor Thompson, Deblina Datta, Susan Hariri, Lauren Cole, Lana Ashley, Jetty Alverson, Michelle Hulbert, Won Silva, Sean Altekruse, Samuel Hirsch, Martha Campbell-Thompson, Amy Wright, Kelley Durden, Jill MacKinnon, Carlos Alvarez, Hugh Luk, David Horio, Shoji Ikeda, Michael Green, Catherine Grafel-Anderson, Rayna Weise, Freda Selk, Dan Olson, Thomas Tucker, Amy Christian, Susan Brossoie, Joe House, Myles G. Cockburn, Andre Kim

Research output: Contribution to journal › Article › peer-review

90 Scopus citations

Abstract

We conducted a study to determine prevalence of HPV types in oropharyngeal cancers in the United States and establish a prevaccine baseline for monitoring the impact of vaccination. HPV DNA was extracted from tumor tissue samples from patients in whom cancer was diagnosed during 1995-2005. The samples were obtained from cancer registries and Residual Tissue Repository Program sites in the United States. HPV was detected and typed by using PCR reverse line blot assays. Among 557 invasive oropharyngeal squamous cell carcinomas, 72% were positive for HPV and 62% for vaccine types HPV16 or 18. Prevalence of HPV- 16/18 was lower in women (53%) than in men (66%), and lower in non-Hispanic Black patients (31%) than in other racial/ ethnic groups (68%-80%). Results indicate that vaccines could prevent most oropharyngeal cancers in the United States, but their effect may vary by demographic variables.

Original language	English
Pages (from-to)	822-828
Number of pages	7
Journal	Emerging Infectious Diseases
Volume	20
Issue number	5
DOIs	https://doi.org/10.3201/eid2005.131311
State	Published - May 2014

Funding

Funders	Funder number
National Institutes of Health (NIH)	P30CA177558
National Childhood Cancer Registry – National Cancer Institute	P30CA086862

ASJC Scopus subject areas

Epidemiology
Microbiology (medical)
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3201/eid2005.131311

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Steinau, M., Saraiya, M., Goodman, M. T., Peters, E. S., Watson, M., Cleveland, J. L., Lynch, C. F., Wilkinson, E. J., Hernandez, B. Y., Copeland, G., Saber, M. S., Hopenhayn, C., Huang, Y., Cozen, W., Lyu, C., Unger, E. R., Ellis, B., Madero, N., Reid, E., ... Kim, A. (2014). Human papillomavirus prevalence in oropharyngeal cancer before vaccine introduction, United States. Emerging Infectious Diseases, 20(5), 822-828. https://doi.org/10.3201/eid2005.131311

@article{f7ec05a852544130b714e9633cb3450c,

title = "Human papillomavirus prevalence in oropharyngeal cancer before vaccine introduction, United States",

abstract = "We conducted a study to determine prevalence of HPV types in oropharyngeal cancers in the United States and establish a prevaccine baseline for monitoring the impact of vaccination. HPV DNA was extracted from tumor tissue samples from patients in whom cancer was diagnosed during 1995-2005. The samples were obtained from cancer registries and Residual Tissue Repository Program sites in the United States. HPV was detected and typed by using PCR reverse line blot assays. Among 557 invasive oropharyngeal squamous cell carcinomas, 72\% were positive for HPV and 62\% for vaccine types HPV16 or 18. Prevalence of HPV- 16/18 was lower in women (53\%) than in men (66\%), and lower in non-Hispanic Black patients (31\%) than in other racial/ ethnic groups (68\%-80\%). Results indicate that vaccines could prevent most oropharyngeal cancers in the United States, but their effect may vary by demographic variables.",

author = "Martin Steinau and Mona Saraiya and Goodman, \{Marc T.\} and Peters, \{Edward S.\} and Meg Watson and Cleveland, \{Jennifer L.\} and Lynch, \{Charles F.\} and Wilkinson, \{Edward J.\} and Hernandez, \{Brenda Y.\} and Glen Copeland and Saber, \{Maria S.\} and Claudia Hopenhayn and Youjie Huang and Wendy Cozen and Christopher Lyu and Unger, \{Elizabeth R.\} and Bruce Ellis and Natalie Madero and Emily Reid and Donna Little and April Greek and Dale Rhoda and Gieseke, \{Linda Delma\} and Stephanie Ashcraft and Katherine Gideon and Tara Ruhlen and Scarbrough, \{Mariela Z.\} and Trevor Thompson and Deblina Datta and Susan Hariri and Lauren Cole and Lana Ashley and Jetty Alverson and Michelle Hulbert and Won Silva and Sean Altekruse and Samuel Hirsch and Martha Campbell-Thompson and Amy Wright and Kelley Durden and Jill MacKinnon and Carlos Alvarez and Hugh Luk and David Horio and Shoji Ikeda and Michael Green and Catherine Grafel-Anderson and Rayna Weise and Freda Selk and Dan Olson and Thomas Tucker and Amy Christian and Susan Brossoie and Joe House and Cockburn, \{Myles G.\} and Andre Kim",

year = "2014",

month = may,

doi = "10.3201/eid2005.131311",

language = "English",

volume = "20",

pages = "822--828",

number = "5",

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Steinau, M, Saraiya, M, Goodman, MT, Peters, ES, Watson, M, Cleveland, JL, Lynch, CF, Wilkinson, EJ, Hernandez, BY, Copeland, G, Saber, MS, Hopenhayn, C, Huang, Y, Cozen, W, Lyu, C, Unger, ER, Ellis, B, Madero, N, Reid, E, Little, D, Greek, A, Rhoda, D, Gieseke, LD, Ashcraft, S, Gideon, K, Ruhlen, T, Scarbrough, MZ, Thompson, T, Datta, D, Hariri, S, Cole, L, Ashley, L, Alverson, J, Hulbert, M, Silva, W, Altekruse, S, Hirsch, S, Campbell-Thompson, M, Wright, A, Durden, K, MacKinnon, J, Alvarez, C, Luk, H, Horio, D, Ikeda, S, Green, M, Grafel-Anderson, C, Weise, R, Selk, F, Olson, D, Tucker, T, Christian, A, Brossoie, S, House, J, Cockburn, MG & Kim, A 2014, 'Human papillomavirus prevalence in oropharyngeal cancer before vaccine introduction, United States', Emerging Infectious Diseases, vol. 20, no. 5, pp. 822-828. https://doi.org/10.3201/eid2005.131311

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T1 - Human papillomavirus prevalence in oropharyngeal cancer before vaccine introduction, United States

AU - Steinau, Martin

AU - Saraiya, Mona

AU - Goodman, Marc T.

AU - Peters, Edward S.

AU - Watson, Meg

AU - Cleveland, Jennifer L.

AU - Lynch, Charles F.

AU - Wilkinson, Edward J.

AU - Hernandez, Brenda Y.

AU - Copeland, Glen

AU - Saber, Maria S.

AU - Hopenhayn, Claudia

AU - Huang, Youjie

AU - Cozen, Wendy

AU - Lyu, Christopher

AU - Unger, Elizabeth R.

AU - Ellis, Bruce

AU - Madero, Natalie

AU - Reid, Emily

AU - Little, Donna

AU - Greek, April

AU - Rhoda, Dale

AU - Gieseke, Linda Delma

AU - Ashcraft, Stephanie

AU - Gideon, Katherine

AU - Ruhlen, Tara

AU - Scarbrough, Mariela Z.

AU - Thompson, Trevor

AU - Datta, Deblina

AU - Hariri, Susan

AU - Cole, Lauren

AU - Ashley, Lana

AU - Alverson, Jetty

AU - Hulbert, Michelle

AU - Silva, Won

AU - Altekruse, Sean

AU - Hirsch, Samuel

AU - Campbell-Thompson, Martha

AU - Wright, Amy

AU - Durden, Kelley

AU - MacKinnon, Jill

AU - Alvarez, Carlos

AU - Luk, Hugh

AU - Horio, David

AU - Ikeda, Shoji

AU - Green, Michael

AU - Grafel-Anderson, Catherine

AU - Weise, Rayna

AU - Selk, Freda

AU - Olson, Dan

AU - Tucker, Thomas

AU - Christian, Amy

AU - Brossoie, Susan

AU - House, Joe

AU - Cockburn, Myles G.

AU - Kim, Andre

PY - 2014/5

Y1 - 2014/5

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AB - We conducted a study to determine prevalence of HPV types in oropharyngeal cancers in the United States and establish a prevaccine baseline for monitoring the impact of vaccination. HPV DNA was extracted from tumor tissue samples from patients in whom cancer was diagnosed during 1995-2005. The samples were obtained from cancer registries and Residual Tissue Repository Program sites in the United States. HPV was detected and typed by using PCR reverse line blot assays. Among 557 invasive oropharyngeal squamous cell carcinomas, 72% were positive for HPV and 62% for vaccine types HPV16 or 18. Prevalence of HPV- 16/18 was lower in women (53%) than in men (66%), and lower in non-Hispanic Black patients (31%) than in other racial/ ethnic groups (68%-80%). Results indicate that vaccines could prevent most oropharyngeal cancers in the United States, but their effect may vary by demographic variables.

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DO - 10.3201/eid2005.131311

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SN - 1080-6040

VL - 20

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JO - Emerging Infectious Diseases

JF - Emerging Infectious Diseases

IS - 5

ER -

Human papillomavirus prevalence in oropharyngeal cancer before vaccine introduction, United States

Abstract

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ASJC Scopus subject areas

UN SDGs

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