Human serum amyloid A protein inhibits hepatitis C virus entry into cells

Zhaohui Cai; Lei Cai; Jieyun Jiang; Kyung Soo Chang; Deneys R. Van Der Westhuyzen; Guangxiang Luo

doi:10.1128/JVI.02627-06

Human serum amyloid A protein inhibits hepatitis C virus entry into cells

Zhaohui Cai, Lei Cai, Jieyun Jiang, Kyung Soo Chang, Deneys R. Van Der Westhuyzen, Guangxiang Luo

Microbiology, Immunology, and Molecular Genetics

Research output: Contribution to journal › Article › peer-review

65 Scopus citations

Abstract

Serum amyloid A (SAA) is an acute-phase protein induced by a variety of inflammatory stimuli, including bacterial and viral infections. SAA was recently found to function as an opsonin for gram-negative bacteria. We report here that SAA inhibited hepatitis C virus (HCV) infection in cultured cells. SAA reduced HCV infectivity in a dose-dependent manner when added during HCV infection but not after virus entry. SAA bound HCV virions and specifically blocked HCV entry but did not affect virus attachment. These findings suggest that SAA functions as part of the host innate immune defense mechanisms against HCV infection in humans.

Original language	English
Pages (from-to)	6128-6133
Number of pages	6
Journal	Journal of Virology
Volume	81
Issue number	11
DOIs	https://doi.org/10.1128/JVI.02627-06
State	Published - Jun 2007

ASJC Scopus subject areas

Microbiology
Immunology
Insect Science
Virology

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10.1128/JVI.02627-06

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title = "Human serum amyloid A protein inhibits hepatitis C virus entry into cells",

abstract = "Serum amyloid A (SAA) is an acute-phase protein induced by a variety of inflammatory stimuli, including bacterial and viral infections. SAA was recently found to function as an opsonin for gram-negative bacteria. We report here that SAA inhibited hepatitis C virus (HCV) infection in cultured cells. SAA reduced HCV infectivity in a dose-dependent manner when added during HCV infection but not after virus entry. SAA bound HCV virions and specifically blocked HCV entry but did not affect virus attachment. These findings suggest that SAA functions as part of the host innate immune defense mechanisms against HCV infection in humans.",

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T1 - Human serum amyloid A protein inhibits hepatitis C virus entry into cells

AU - Cai, Zhaohui

AU - Cai, Lei

AU - Jiang, Jieyun

AU - Chang, Kyung Soo

AU - Van Der Westhuyzen, Deneys R.

AU - Luo, Guangxiang

PY - 2007/6

Y1 - 2007/6

N2 - Serum amyloid A (SAA) is an acute-phase protein induced by a variety of inflammatory stimuli, including bacterial and viral infections. SAA was recently found to function as an opsonin for gram-negative bacteria. We report here that SAA inhibited hepatitis C virus (HCV) infection in cultured cells. SAA reduced HCV infectivity in a dose-dependent manner when added during HCV infection but not after virus entry. SAA bound HCV virions and specifically blocked HCV entry but did not affect virus attachment. These findings suggest that SAA functions as part of the host innate immune defense mechanisms against HCV infection in humans.

AB - Serum amyloid A (SAA) is an acute-phase protein induced by a variety of inflammatory stimuli, including bacterial and viral infections. SAA was recently found to function as an opsonin for gram-negative bacteria. We report here that SAA inhibited hepatitis C virus (HCV) infection in cultured cells. SAA reduced HCV infectivity in a dose-dependent manner when added during HCV infection but not after virus entry. SAA bound HCV virions and specifically blocked HCV entry but did not affect virus attachment. These findings suggest that SAA functions as part of the host innate immune defense mechanisms against HCV infection in humans.

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JO - Journal of Virology

JF - Journal of Virology

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Human serum amyloid A protein inhibits hepatitis C virus entry into cells

Abstract

ASJC Scopus subject areas

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