Abstract
Serum amyloid A (SAA) is an acute-phase protein induced by a variety of inflammatory stimuli, including bacterial and viral infections. SAA was recently found to function as an opsonin for gram-negative bacteria. We report here that SAA inhibited hepatitis C virus (HCV) infection in cultured cells. SAA reduced HCV infectivity in a dose-dependent manner when added during HCV infection but not after virus entry. SAA bound HCV virions and specifically blocked HCV entry but did not affect virus attachment. These findings suggest that SAA functions as part of the host innate immune defense mechanisms against HCV infection in humans.
| Original language | English |
|---|---|
| Pages (from-to) | 6128-6133 |
| Number of pages | 6 |
| Journal | Journal of Virology |
| Volume | 81 |
| Issue number | 11 |
| DOIs | |
| State | Published - Jun 2007 |
Funding
| Funders | Funder number |
|---|---|
| National Institute of Allergy and Infectious Diseases | R01AI051592 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
ASJC Scopus subject areas
- Microbiology
- Immunology
- Insect Science
- Virology
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