Human striatal cholinergic neurons in development, aging and Alzheimer's disease

Changiz Geula, Hajime Tokuno, Louis Hersh, M. -Marsel Mesulam

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


The cross-sectional area of cholinergic neurons stained immunohistochemically for choline acetyltransferase were measured in the striatum of infants, young adults, aged individuals and patients with Alzheimer's disease. Cholinergic neurons were distributed throughout the caudate nucleus and the putamen and displayed no significant variations in size across the two structures. The cross-sectional area of striatal cholinergic neurons was smaller in infants as compared with all the other groups examined. No significant changes were observed in the size of these neurons as a consequence of aging or Alzheimer's disease.

Original languageEnglish
Pages (from-to)310-312
Number of pages3
JournalBrain Research
Issue number2
StatePublished - Feb 5 1990

Bibliographical note

Funding Information:
We would like to thank Leah Christie and Kristin Loud for expert secretarial and technical assistance. We are grateful to Drs. Catherine Joachim, Bruce Price and William Schoene for providing human brain tissue. Supported in part by an NRSA award (AG05455), an Alzheimer's Disease Research Center Grant (AG05134), the Alzheimer's Disease and Related Disorders Association and by a Javits Neuroscience Investigator Award (NS20285).


  • Aging
  • Alzheimer's disease
  • Cholinergic neuron
  • Development
  • Neuronal size
  • Striatum

ASJC Scopus subject areas

  • General Neuroscience
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology


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