Human striatal cholinergic neurons in development, aging and Alzheimer's disease

Changiz Geula; Hajime Tokuno; Louis Hersh; M. -Marsel Mesulam

doi:10.1016/0006-8993(90)90414-7

Human striatal cholinergic neurons in development, aging and Alzheimer's disease

Changiz Geula, Hajime Tokuno, Louis Hersh, M. -Marsel Mesulam

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

The cross-sectional area of cholinergic neurons stained immunohistochemically for choline acetyltransferase were measured in the striatum of infants, young adults, aged individuals and patients with Alzheimer's disease. Cholinergic neurons were distributed throughout the caudate nucleus and the putamen and displayed no significant variations in size across the two structures. The cross-sectional area of striatal cholinergic neurons was smaller in infants as compared with all the other groups examined. No significant changes were observed in the size of these neurons as a consequence of aging or Alzheimer's disease.

Original language	English
Pages (from-to)	310-312
Number of pages	3
Journal	Brain Research
Volume	508
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(90)90414-7
State	Published - Feb 5 1990

Bibliographical note

Funding Information:
We would like to thank Leah Christie and Kristin Loud for expert secretarial and technical assistance. We are grateful to Drs. Catherine Joachim, Bruce Price and William Schoene for providing human brain tissue. Supported in part by an NRSA award (AG05455), an Alzheimer's Disease Research Center Grant (AG05134), the Alzheimer's Disease and Related Disorders Association and by a Javits Neuroscience Investigator Award (NS20285).

Funding

We would like to thank Leah Christie and Kristin Loud for expert secretarial and technical assistance. We are grateful to Drs. Catherine Joachim, Bruce Price and William Schoene for providing human brain tissue. Supported in part by an NRSA award (AG05455), an Alzheimer's Disease Research Center Grant (AG05134), the Alzheimer's Disease and Related Disorders Association and by a Javits Neuroscience Investigator Award (NS20285).

Funders	Funder number
Greek Association of Alzheimer's Disease and Related Disorders	NS20285
National Institute on Aging	F32AG005455
National Institute on Aging
Alzheimer's Disease Research Foundation	AG05134
Alzheimer's Disease Research Foundation
Israel National Road Safety Authority	AG05455
Israel National Road Safety Authority

Keywords

Aging
Alzheimer's disease
Cholinergic neuron
Development
Neuronal size
Striatum

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/0006-8993(90)90414-7

Cite this

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title = "Human striatal cholinergic neurons in development, aging and Alzheimer's disease",

abstract = "The cross-sectional area of cholinergic neurons stained immunohistochemically for choline acetyltransferase were measured in the striatum of infants, young adults, aged individuals and patients with Alzheimer's disease. Cholinergic neurons were distributed throughout the caudate nucleus and the putamen and displayed no significant variations in size across the two structures. The cross-sectional area of striatal cholinergic neurons was smaller in infants as compared with all the other groups examined. No significant changes were observed in the size of these neurons as a consequence of aging or Alzheimer's disease.",

keywords = "Aging, Alzheimer's disease, Cholinergic neuron, Development, Neuronal size, Striatum",

author = "Changiz Geula and Hajime Tokuno and Louis Hersh and \{-Marsel Mesulam\}, M.",

note = "Funding Information: We would like to thank Leah Christie and Kristin Loud for expert secretarial and technical assistance. We are grateful to Drs. Catherine Joachim, Bruce Price and William Schoene for providing human brain tissue. Supported in part by an NRSA award (AG05455), an Alzheimer's Disease Research Center Grant (AG05134), the Alzheimer's Disease and Related Disorders Association and by a Javits Neuroscience Investigator Award (NS20285).",

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doi = "10.1016/0006-8993(90)90414-7",

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AU - Geula, Changiz

AU - Tokuno, Hajime

AU - Hersh, Louis

AU - -Marsel Mesulam, M.

N1 - Funding Information: We would like to thank Leah Christie and Kristin Loud for expert secretarial and technical assistance. We are grateful to Drs. Catherine Joachim, Bruce Price and William Schoene for providing human brain tissue. Supported in part by an NRSA award (AG05455), an Alzheimer's Disease Research Center Grant (AG05134), the Alzheimer's Disease and Related Disorders Association and by a Javits Neuroscience Investigator Award (NS20285).

PY - 1990/2/5

Y1 - 1990/2/5

N2 - The cross-sectional area of cholinergic neurons stained immunohistochemically for choline acetyltransferase were measured in the striatum of infants, young adults, aged individuals and patients with Alzheimer's disease. Cholinergic neurons were distributed throughout the caudate nucleus and the putamen and displayed no significant variations in size across the two structures. The cross-sectional area of striatal cholinergic neurons was smaller in infants as compared with all the other groups examined. No significant changes were observed in the size of these neurons as a consequence of aging or Alzheimer's disease.

AB - The cross-sectional area of cholinergic neurons stained immunohistochemically for choline acetyltransferase were measured in the striatum of infants, young adults, aged individuals and patients with Alzheimer's disease. Cholinergic neurons were distributed throughout the caudate nucleus and the putamen and displayed no significant variations in size across the two structures. The cross-sectional area of striatal cholinergic neurons was smaller in infants as compared with all the other groups examined. No significant changes were observed in the size of these neurons as a consequence of aging or Alzheimer's disease.

KW - Aging

KW - Alzheimer's disease

KW - Cholinergic neuron

KW - Development

KW - Neuronal size

KW - Striatum

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SN - 0006-8993

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Human striatal cholinergic neurons in development, aging and Alzheimer's disease

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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