Abstract
The ATP/ADP ratio reflects mitochondrial function and has been reported to be influenced by the size of the Huntington disease gene (HD) repeat. Impaired mitochondrial function has long been implicated in the pathogenesis of Parkinson's disease (PD), and therefore, we evaluated the relationship of the HD CAG repeat size to PD onset age in a large sample of familial PD cases. PD affected siblings (n = 495), with known onset ages from 248 families, were genotyped for the HD CAG repeat. Genotyping failed in 11 cases leaving 484 for analysis, including 35 LRRK2 carriers. All cases had HD CAG repeats (range, 15-34) below the clinical range for HD, although 5.2% of the sample (n = 25) had repeats in the intermediate range (the intermediate range lower limit = 27; upper limit = 35 repeats), suggesting that the prevalence of intermediate allele carriers in the general population is significant. No relation between the HD CAG repeat size and the age at onset for PD was found in this sample of familial PD.
Original language | English |
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Pages (from-to) | 1596-1601 |
Number of pages | 6 |
Journal | Movement Disorders |
Volume | 23 |
Issue number | 11 |
DOIs | |
State | Published - Aug 15 2008 |
Funding
Funders | Funder number |
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Institute of Neurological Disorders and Stroke National Advisory Neurological Disorders and Stroke Council | R01NS032765 |
Institute of Neurological Disorders and Stroke National Advisory Neurological Disorders and Stroke Council |
Keywords
- CAG repeat
- Genetics
- Huntington's disease
- Mitochondria
- Onset age
- Parkinson's disease
ASJC Scopus subject areas
- Neurology
- Clinical Neurology