Abstract
Hurgadacin (1), a 24,25-bishomo-26-methylenecholesterol was isolated from the soft coral Sinularia polydactyla, collected from the Red Sea, near Hurghada at the Egyptian coast. The new steroid 1 was isolated together with the closely related polyhydroxy steroids 24-methylenecholestane-3β,5α,6β- triol (2) and 24-methylenecholestane-1α,3β,5α,6β, 11α-pentol (3), in addition to the sesquiterpene lactiflorenol (4) and the trinorcarotenolide acetate peridinin (5), The structures of the isolated compounds were confirmed by intensive studies of their 1D and 2D NMR spectra and mass data. The antimicrobial and cytotoxic activities of the soft coral extract and the corresponding constituents were evaluated against diverse pathogenic microorganisms and brine shrimps, respectively.
| Original language | English |
|---|---|
| Pages (from-to) | 866-873 |
| Number of pages | 8 |
| Journal | Steroids |
| Volume | 78 |
| Issue number | 9 |
| DOIs | |
| State | Published - 2013 |
Bibliographical note
Funding Information:The authors are greatly thankful to Prof. H. Laatsch, Institute of Organic and Biomolecular Chemistry, University of Göttingen, Germany, for his lab facilities and support. We thank Dr. H. Frauendorf and Mr. R. Machinek for MS and NMR measurements. Mrs. F. Lissy and Mr. A. Kohl are deeply appreciated for biological activity testing and technical assistance, respectively. We thank Dr. Madan K. Kharel (College of Pharmacy, University of Kentucky, USA) for the insightful discussion regarding the biosynthesis of the Hurgadacin. M. S. thanks the German Academic Exchange Service (DAAD) for a short-term grant.
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
Keywords
- Biological activity
- Hurgadacin
- Sinularia polydactyla
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Endocrinology
- Pharmacology
- Clinical Biochemistry
- Organic Chemistry