Hydrogel nanocomposites as remote-controlled biomaterials

Nitin S. Satarkar, J. Zach Hilt

Research output: Contribution to journalArticlepeer-review

184 Scopus citations

Abstract

Nanocomposite hydrogels are a new class of intelligent materials which have recently attracted interest as biomaterials. In this study, magnetic nanocomposites of temperature-sensitive hydrogels have been developed and demonstrated to be responsive to alternating magnetic fields. Nanocomposites were synthesized by incorporation of superparamagnetic Fe3O4 particles in negative temperature-sensitive poly(N-isopropylacrylamide) hydrogels. The systems were characterized for temperature-responsive swelling, remote heating on application of an alternating magnetic field and remote-controlled drug delivery applications. The rise in temperature in external alternating magnetic field depends on the Fe3O4 particle loading of the system. Preliminary studies on remote-controlled drug release showed reduced release in the presence of an alternating magnetic field.

Original languageEnglish
Pages (from-to)11-16
Number of pages6
JournalActa Biomaterialia
Volume4
Issue number1
DOIs
StatePublished - Jan 2008

Keywords

  • Drug delivery
  • Hydrogel
  • Magnetic
  • Nanocomposite
  • Remote control

ASJC Scopus subject areas

  • Biotechnology
  • Biomaterials
  • Biochemistry
  • Biomedical Engineering
  • Molecular Biology

Fingerprint

Dive into the research topics of 'Hydrogel nanocomposites as remote-controlled biomaterials'. Together they form a unique fingerprint.

Cite this