Hyperactivity in preweanling rats following postnatal alcohol exposure

Ted Melcer, David Gonzalez, Susan Barron, Edward P. Riley

Research output: Contribution to journalArticlepeer-review

35 Scopus citations


Neonatal alcohol exposure in rats has been used as a model to study the effects of third-trimester alcohol consumption in humans. In the present research, male and female rat pups were artificially reared (AR) and received condensed alcohol exposure (6 g/kg/day or 4 g/kg/day) on postnatal days (PNs) 4 through 9. Controls consisted of both artificially reared animals receiving maltose-dextrin substituted for alcohol and normally reared animals. These rats were tested for open-field activity at 18 days of age for four days. Both male and female rat pups that received the high dose of alcohol (6 g/kg/day) evidenced overactivity relative to pups in both control groups. These findings extend previous work and indicate that neonatal alcohol exposure can induce hyperactivity in young male rats.

Original languageEnglish
Pages (from-to)41-45
Number of pages5
Issue number1
StatePublished - 1994

Bibliographical note

Funding Information:
This work was supported in part by NIAAA grant E.P.R.


  • FAS
  • Hyperactivity
  • Postnatal alcohol exposure
  • Preweanling rats

ASJC Scopus subject areas

  • Health(social science)
  • Biochemistry
  • Toxicology
  • Neurology
  • Behavioral Neuroscience


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