Hyperactivity in preweanling rats following postnatal alcohol exposure

Ted Melcer; David Gonzalez; Susan Barron; Edward P. Riley

doi:10.1016/0741-8329(94)90010-8

Hyperactivity in preweanling rats following postnatal alcohol exposure

Ted Melcer, David Gonzalez, Susan Barron, Edward P. Riley

Psychology

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

Neonatal alcohol exposure in rats has been used as a model to study the effects of third-trimester alcohol consumption in humans. In the present research, male and female rat pups were artificially reared (AR) and received condensed alcohol exposure (6 g/kg/day or 4 g/kg/day) on postnatal days (PNs) 4 through 9. Controls consisted of both artificially reared animals receiving maltose-dextrin substituted for alcohol and normally reared animals. These rats were tested for open-field activity at 18 days of age for four days. Both male and female rat pups that received the high dose of alcohol (6 g/kg/day) evidenced overactivity relative to pups in both control groups. These findings extend previous work and indicate that neonatal alcohol exposure can induce hyperactivity in young male rats.

Original language	English
Pages (from-to)	41-45
Number of pages	5
Journal	Alcohol
Volume	11
Issue number	1
DOIs	https://doi.org/10.1016/0741-8329(94)90010-8
State	Published - 1994

Bibliographical note

Funding Information:
This work was supported in part by NIAAA grant E.P.R.

Keywords

FAS
Hyperactivity
Postnatal alcohol exposure
Preweanling rats

ASJC Scopus subject areas

Health(social science)
Biochemistry
Toxicology
Neurology
Behavioral Neuroscience

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10.1016/0741-8329(94)90010-8

Cite this

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title = "Hyperactivity in preweanling rats following postnatal alcohol exposure",

abstract = "Neonatal alcohol exposure in rats has been used as a model to study the effects of third-trimester alcohol consumption in humans. In the present research, male and female rat pups were artificially reared (AR) and received condensed alcohol exposure (6 g/kg/day or 4 g/kg/day) on postnatal days (PNs) 4 through 9. Controls consisted of both artificially reared animals receiving maltose-dextrin substituted for alcohol and normally reared animals. These rats were tested for open-field activity at 18 days of age for four days. Both male and female rat pups that received the high dose of alcohol (6 g/kg/day) evidenced overactivity relative to pups in both control groups. These findings extend previous work and indicate that neonatal alcohol exposure can induce hyperactivity in young male rats.",

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AU - Melcer, Ted

AU - Gonzalez, David

AU - Barron, Susan

AU - Riley, Edward P.

N1 - Funding Information: This work was supported in part by NIAAA grant E.P.R.

PY - 1994

Y1 - 1994

N2 - Neonatal alcohol exposure in rats has been used as a model to study the effects of third-trimester alcohol consumption in humans. In the present research, male and female rat pups were artificially reared (AR) and received condensed alcohol exposure (6 g/kg/day or 4 g/kg/day) on postnatal days (PNs) 4 through 9. Controls consisted of both artificially reared animals receiving maltose-dextrin substituted for alcohol and normally reared animals. These rats were tested for open-field activity at 18 days of age for four days. Both male and female rat pups that received the high dose of alcohol (6 g/kg/day) evidenced overactivity relative to pups in both control groups. These findings extend previous work and indicate that neonatal alcohol exposure can induce hyperactivity in young male rats.

AB - Neonatal alcohol exposure in rats has been used as a model to study the effects of third-trimester alcohol consumption in humans. In the present research, male and female rat pups were artificially reared (AR) and received condensed alcohol exposure (6 g/kg/day or 4 g/kg/day) on postnatal days (PNs) 4 through 9. Controls consisted of both artificially reared animals receiving maltose-dextrin substituted for alcohol and normally reared animals. These rats were tested for open-field activity at 18 days of age for four days. Both male and female rat pups that received the high dose of alcohol (6 g/kg/day) evidenced overactivity relative to pups in both control groups. These findings extend previous work and indicate that neonatal alcohol exposure can induce hyperactivity in young male rats.

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KW - Preweanling rats

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Hyperactivity in preweanling rats following postnatal alcohol exposure

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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