Physiological studies of olfactory receptor cells have focused on excitatory responses, in part because the evidence for inhibitory responses from extracellular recordings, although long-standing, has been equivocal. Intracellular recording from the olfactory cells of two species of lobsters revealed that small but concentrationdependent and repeatable hyperpolarizing receptor potentials could be evoked by a mixture of L-arginine, L-cysteine and L-proline, as well as by histamine. Large, depolarizing receptor potentials were evoked in the same cells by a complex odor mixture. Simultaneous application of depolarizing and hyperpolarizing stimuli reduced the magnitude of the evoked depolarization. These results imply that multiple, opposing transduction mechanisms are present in single lobster olfactory receptor cells and reveal a noncompetitive mechanism for peripheral mixture suppression.
|Number of pages||11|
|State||Published - Oct 1989|
Bibliographical noteFunding Information:
We thank Ms M.Milstead and Mr J.Netherton for preparing the illustrations. Financial support was provided by NIMH Fellowship F31MH09495, NSF Award 88-10261 and the Grass Foundation.
ASJC Scopus subject areas
- Sensory Systems
- Physiology (medical)
- Behavioral Neuroscience