Hypoglycaemic activity of Scoparia dulcis L. extract in alloxan induced hyperglycaemic rats

L. Pari, S. Venkateswaran

Research output: Contribution to journalArticlepeer-review

47 Scopus citations

Abstract

Scoparia dulcis L. commonly known as 'Sweet Broomweed' is widely used in Indian folk medicine for the treatment of diabetes mellitus. Oral administration of 0.15, 0.30 and 0.45 g/kg body weight of the aqueous extract of the Scoparia dulcis leaves (SLEt) for 45 days resulted in a significant reduction in blood glucose, glycosylated haemoglobin and an increase in total haemoglobin but in the case of 0.45 g/kg body weight the effect was highly significant. The aqueous extract also prevented a decrease in the body weight. An oral glucose tolerance test was also performed in experimental diabetic rats, in which there was a significant improvement in glucose tolerance in animals treated with SLEt and the effect was comparable to that of glibenclamide.

Original languageEnglish
Pages (from-to)662-664
Number of pages3
JournalPhytotherapy Research
Volume16
Issue number7
DOIs
StatePublished - Nov 2002

Keywords

  • Alloxan
  • Diabetes
  • Hypoglycaemic effect
  • Scoparia dulcis

ASJC Scopus subject areas

  • Pharmacology

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