ICAM1 and VCAM1 polymorphisms, coronary artery calcium, and circulating levels of soluble ICAM-1: The multi-ethnic study of atherosclerosis (MESA)

Suzette J. Bielinski; James S. Pankow; Na Li; Fang Chi Hsu; Sara D. Adar; Nancy Swords Jenny; Donald W. Bowden; Bruce A. Wasserman; Donna Arnett

doi:10.1016/j.atherosclerosis.2008.02.031

ICAM1 and VCAM1 polymorphisms, coronary artery calcium, and circulating levels of soluble ICAM-1: The multi-ethnic study of atherosclerosis (MESA)

Suzette J. Bielinski, James S. Pankow, Na Li, Fang Chi Hsu, Sara D. Adar, Nancy Swords Jenny, Donald W. Bowden, Bruce A. Wasserman, Donna Arnett

Research output: Contribution to journal › Article › peer-review

55 Scopus citations

Abstract

Intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) may be important contributors to the development and progression of atherosclerosis. Using a stratified random sample of 2880 participants of the Multi-Ethnic Study of Atherosclerosis we investigated the relationship of 12 ICAM1 and 17 VCAM1 SNPs and coronary artery calcium (CAC) and ICAM1 SNPs and circulating levels of soluble ICAM-1 (sICAM-1). There were no ICAM1 or VCAM1 SNPs significantly associated with CAC in any of the four race/ethnic groups. In a subset of 1451 subjects with sICAM-1 measurements, we observed a significant association with rs5491 in all four race/ethnic groups corroborating previous research that has shown that the T-allele of rs5491 interferes with the monoclonal antibody used to measure sICAM-1 in this study. After excluding all rs5491 T-allele carriers, several ICAM1 SNPs were significantly associated with sICAM-1 levels; rs5496 in African Americans, rs5498 and rs3093030 in European Americans, and rs1799969 in Hispanics. Our results identified ICAM1 polymorphisms that were significantly associated with sICAM-1 level but not CAC, a subclinical marker of atherosclerosis.

Original language	English
Pages (from-to)	339-344
Number of pages	6
Journal	Atherosclerosis
Volume	201
Issue number	2
DOIs	https://doi.org/10.1016/j.atherosclerosis.2008.02.031
State	Published - Dec 2008

Bibliographical note

Funding Information:
The authors thank the other investigators, the staff, and the participants of the MESA study for their valuable contributions. This research was supported by contracts N01-HC-95159 through N01-HC-95165, N01-HC-95169, R01-HL071250 through R01-HL071252, R01-HL071259, R01-HL071051, and R01-HL071205 from the National Heart, Lung, and Blood Institute. A full list of participating MESA investigators and institutions can be found at http://www.mesa-nhlbi.org .

Funding

The authors thank the other investigators, the staff, and the participants of the MESA study for their valuable contributions. This research was supported by contracts N01-HC-95159 through N01-HC-95165, N01-HC-95169, R01-HL071250 through R01-HL071252, R01-HL071259, R01-HL071051, and R01-HL071205 from the National Heart, Lung, and Blood Institute. A full list of participating MESA investigators and institutions can be found at http://www.mesa-nhlbi.org .

Funders	Funder number
National Heart, Lung, and Blood Institute (NHLBI)	R01HL071250

Keywords

Coronary artery calcium
Gene
Haplotypes
Intercellular adhesion molecule-1 (ICAM-1)
Single nucleotide polymorphism (SNP)
Soluble intercellular adhesion molecule-1 (sICAM-1)
Vascular adhesion molecule-1 (VCAM-1)

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/j.atherosclerosis.2008.02.031

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@article{d82fe50c9f0e4498b06690f4ff609176,

title = "ICAM1 and VCAM1 polymorphisms, coronary artery calcium, and circulating levels of soluble ICAM-1: The multi-ethnic study of atherosclerosis (MESA)",

abstract = "Intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) may be important contributors to the development and progression of atherosclerosis. Using a stratified random sample of 2880 participants of the Multi-Ethnic Study of Atherosclerosis we investigated the relationship of 12 ICAM1 and 17 VCAM1 SNPs and coronary artery calcium (CAC) and ICAM1 SNPs and circulating levels of soluble ICAM-1 (sICAM-1). There were no ICAM1 or VCAM1 SNPs significantly associated with CAC in any of the four race/ethnic groups. In a subset of 1451 subjects with sICAM-1 measurements, we observed a significant association with rs5491 in all four race/ethnic groups corroborating previous research that has shown that the T-allele of rs5491 interferes with the monoclonal antibody used to measure sICAM-1 in this study. After excluding all rs5491 T-allele carriers, several ICAM1 SNPs were significantly associated with sICAM-1 levels; rs5496 in African Americans, rs5498 and rs3093030 in European Americans, and rs1799969 in Hispanics. Our results identified ICAM1 polymorphisms that were significantly associated with sICAM-1 level but not CAC, a subclinical marker of atherosclerosis.",

keywords = "Coronary artery calcium, Gene, Haplotypes, Intercellular adhesion molecule-1 (ICAM-1), Single nucleotide polymorphism (SNP), Soluble intercellular adhesion molecule-1 (sICAM-1), Vascular adhesion molecule-1 (VCAM-1)",

author = "Bielinski, {Suzette J.} and Pankow, {James S.} and Na Li and Hsu, {Fang Chi} and Adar, {Sara D.} and Jenny, {Nancy Swords} and Bowden, {Donald W.} and Wasserman, {Bruce A.} and Donna Arnett",

note = "Funding Information: The authors thank the other investigators, the staff, and the participants of the MESA study for their valuable contributions. This research was supported by contracts N01-HC-95159 through N01-HC-95165, N01-HC-95169, R01-HL071250 through R01-HL071252, R01-HL071259, R01-HL071051, and R01-HL071205 from the National Heart, Lung, and Blood Institute. A full list of participating MESA investigators and institutions can be found at http://www.mesa-nhlbi.org . ",

year = "2008",

month = dec,

doi = "10.1016/j.atherosclerosis.2008.02.031",

language = "English",

volume = "201",

pages = "339--344",

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T1 - ICAM1 and VCAM1 polymorphisms, coronary artery calcium, and circulating levels of soluble ICAM-1

T2 - The multi-ethnic study of atherosclerosis (MESA)

AU - Bielinski, Suzette J.

AU - Pankow, James S.

AU - Li, Na

AU - Hsu, Fang Chi

AU - Adar, Sara D.

AU - Jenny, Nancy Swords

AU - Bowden, Donald W.

AU - Wasserman, Bruce A.

AU - Arnett, Donna

N1 - Funding Information: The authors thank the other investigators, the staff, and the participants of the MESA study for their valuable contributions. This research was supported by contracts N01-HC-95159 through N01-HC-95165, N01-HC-95169, R01-HL071250 through R01-HL071252, R01-HL071259, R01-HL071051, and R01-HL071205 from the National Heart, Lung, and Blood Institute. A full list of participating MESA investigators and institutions can be found at http://www.mesa-nhlbi.org .

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N2 - Intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) may be important contributors to the development and progression of atherosclerosis. Using a stratified random sample of 2880 participants of the Multi-Ethnic Study of Atherosclerosis we investigated the relationship of 12 ICAM1 and 17 VCAM1 SNPs and coronary artery calcium (CAC) and ICAM1 SNPs and circulating levels of soluble ICAM-1 (sICAM-1). There were no ICAM1 or VCAM1 SNPs significantly associated with CAC in any of the four race/ethnic groups. In a subset of 1451 subjects with sICAM-1 measurements, we observed a significant association with rs5491 in all four race/ethnic groups corroborating previous research that has shown that the T-allele of rs5491 interferes with the monoclonal antibody used to measure sICAM-1 in this study. After excluding all rs5491 T-allele carriers, several ICAM1 SNPs were significantly associated with sICAM-1 levels; rs5496 in African Americans, rs5498 and rs3093030 in European Americans, and rs1799969 in Hispanics. Our results identified ICAM1 polymorphisms that were significantly associated with sICAM-1 level but not CAC, a subclinical marker of atherosclerosis.

AB - Intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) may be important contributors to the development and progression of atherosclerosis. Using a stratified random sample of 2880 participants of the Multi-Ethnic Study of Atherosclerosis we investigated the relationship of 12 ICAM1 and 17 VCAM1 SNPs and coronary artery calcium (CAC) and ICAM1 SNPs and circulating levels of soluble ICAM-1 (sICAM-1). There were no ICAM1 or VCAM1 SNPs significantly associated with CAC in any of the four race/ethnic groups. In a subset of 1451 subjects with sICAM-1 measurements, we observed a significant association with rs5491 in all four race/ethnic groups corroborating previous research that has shown that the T-allele of rs5491 interferes with the monoclonal antibody used to measure sICAM-1 in this study. After excluding all rs5491 T-allele carriers, several ICAM1 SNPs were significantly associated with sICAM-1 levels; rs5496 in African Americans, rs5498 and rs3093030 in European Americans, and rs1799969 in Hispanics. Our results identified ICAM1 polymorphisms that were significantly associated with sICAM-1 level but not CAC, a subclinical marker of atherosclerosis.

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KW - Haplotypes

KW - Intercellular adhesion molecule-1 (ICAM-1)

KW - Single nucleotide polymorphism (SNP)

KW - Soluble intercellular adhesion molecule-1 (sICAM-1)

KW - Vascular adhesion molecule-1 (VCAM-1)

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DO - 10.1016/j.atherosclerosis.2008.02.031

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C2 - 18420209

AN - SCOPUS:56649089864

SN - 0021-9150

VL - 201

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JO - Atherosclerosis

JF - Atherosclerosis

IS - 2

ER -

ICAM1 and VCAM1 polymorphisms, coronary artery calcium, and circulating levels of soluble ICAM-1: The multi-ethnic study of atherosclerosis (MESA)

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

Access to Document

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