Identification of a potent herbal molecule for the treatment of breast cancer

Srinivas Koduru; Srinivasan Sowmyalakshmi; Raj Kumar; Rohini Gomathinayagam; Jürgen Rohr; Chendil Damodaran

doi:10.1186/1471-2407-9-41

Identification of a potent herbal molecule for the treatment of breast cancer

Srinivas Koduru, Srinivasan Sowmyalakshmi, Raj Kumar, Rohini Gomathinayagam, Jürgen Rohr, Chendil Damodaran

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Background: Breast cancer (BCa)-related mortality still remains the second leading cause of cancer-related deaths worldwide. Patients with BCa have increasingly shown resistance and high toxicity to current chemotherapeutic drugs for which identification of novel targeted therapies are required. Methods: To determine the effect of PDBD on BCa cells, estrogen-receptor positive (ER+)-MCF-7 and estrogen-receptor negative (ER-)-MDA 231 cells were treated with PDBD and the cell viability, apoptotic, cell cycle, Western blot and Promoter assays were performed. Results: PDBD inhibitscell viability of ER+ and ER- BCa cells by inducing apoptosis without causing significant toxicity in normal breast epithelial cells. While dissecting the mechanism of action of PDBD on BCa, we found that PDBD inhibits Akt signaling and its downstream targets such as NF-κB activation, IAP proteins and Bcl-2 expression. On the other hand, activation of JNK/p38 MAPK-mediated pro-apoptotic signaling was observed in both ER+ and ER- BCa cells. Conclusion: These findings suggest that PDBD may have wide therapeutic application in the treatment of BCa.

Original language	English
Article number	41
Journal	BMC Cancer
Volume	9
DOIs	https://doi.org/10.1186/1471-2407-9-41
State	Published - Jan 30 2009

Bibliographical note

Funding Information:
This work was supported by the grant from the Susan G. Komen Breast Cancer Foundation to CD.

Funding

This work was supported by the grant from the Susan G. Komen Breast Cancer Foundation to CD.

Funders	Funder number
Susan G Komen Foundation

ASJC Scopus subject areas

Oncology
Genetics
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1186/1471-2407-9-41

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title = "Identification of a potent herbal molecule for the treatment of breast cancer",

abstract = "Background: Breast cancer (BCa)-related mortality still remains the second leading cause of cancer-related deaths worldwide. Patients with BCa have increasingly shown resistance and high toxicity to current chemotherapeutic drugs for which identification of novel targeted therapies are required. Methods: To determine the effect of PDBD on BCa cells, estrogen-receptor positive (ER+)-MCF-7 and estrogen-receptor negative (ER-)-MDA 231 cells were treated with PDBD and the cell viability, apoptotic, cell cycle, Western blot and Promoter assays were performed. Results: PDBD inhibitscell viability of ER+ and ER- BCa cells by inducing apoptosis without causing significant toxicity in normal breast epithelial cells. While dissecting the mechanism of action of PDBD on BCa, we found that PDBD inhibits Akt signaling and its downstream targets such as NF-κB activation, IAP proteins and Bcl-2 expression. On the other hand, activation of JNK/p38 MAPK-mediated pro-apoptotic signaling was observed in both ER+ and ER- BCa cells. Conclusion: These findings suggest that PDBD may have wide therapeutic application in the treatment of BCa.",

author = "Srinivas Koduru and Srinivasan Sowmyalakshmi and Raj Kumar and Rohini Gomathinayagam and J{\"u}rgen Rohr and Chendil Damodaran",

note = "Funding Information: This work was supported by the grant from the Susan G. Komen Breast Cancer Foundation to CD.",

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doi = "10.1186/1471-2407-9-41",

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T1 - Identification of a potent herbal molecule for the treatment of breast cancer

AU - Koduru, Srinivas

AU - Sowmyalakshmi, Srinivasan

AU - Kumar, Raj

AU - Gomathinayagam, Rohini

AU - Rohr, Jürgen

AU - Damodaran, Chendil

N1 - Funding Information: This work was supported by the grant from the Susan G. Komen Breast Cancer Foundation to CD.

PY - 2009/1/30

Y1 - 2009/1/30

N2 - Background: Breast cancer (BCa)-related mortality still remains the second leading cause of cancer-related deaths worldwide. Patients with BCa have increasingly shown resistance and high toxicity to current chemotherapeutic drugs for which identification of novel targeted therapies are required. Methods: To determine the effect of PDBD on BCa cells, estrogen-receptor positive (ER+)-MCF-7 and estrogen-receptor negative (ER-)-MDA 231 cells were treated with PDBD and the cell viability, apoptotic, cell cycle, Western blot and Promoter assays were performed. Results: PDBD inhibitscell viability of ER+ and ER- BCa cells by inducing apoptosis without causing significant toxicity in normal breast epithelial cells. While dissecting the mechanism of action of PDBD on BCa, we found that PDBD inhibits Akt signaling and its downstream targets such as NF-κB activation, IAP proteins and Bcl-2 expression. On the other hand, activation of JNK/p38 MAPK-mediated pro-apoptotic signaling was observed in both ER+ and ER- BCa cells. Conclusion: These findings suggest that PDBD may have wide therapeutic application in the treatment of BCa.

AB - Background: Breast cancer (BCa)-related mortality still remains the second leading cause of cancer-related deaths worldwide. Patients with BCa have increasingly shown resistance and high toxicity to current chemotherapeutic drugs for which identification of novel targeted therapies are required. Methods: To determine the effect of PDBD on BCa cells, estrogen-receptor positive (ER+)-MCF-7 and estrogen-receptor negative (ER-)-MDA 231 cells were treated with PDBD and the cell viability, apoptotic, cell cycle, Western blot and Promoter assays were performed. Results: PDBD inhibitscell viability of ER+ and ER- BCa cells by inducing apoptosis without causing significant toxicity in normal breast epithelial cells. While dissecting the mechanism of action of PDBD on BCa, we found that PDBD inhibits Akt signaling and its downstream targets such as NF-κB activation, IAP proteins and Bcl-2 expression. On the other hand, activation of JNK/p38 MAPK-mediated pro-apoptotic signaling was observed in both ER+ and ER- BCa cells. Conclusion: These findings suggest that PDBD may have wide therapeutic application in the treatment of BCa.

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Identification of a potent herbal molecule for the treatment of breast cancer

Abstract

Bibliographical note

Funding

ASJC Scopus subject areas

UN SDGs

Access to Document

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