Identification of unprecedented purine-containing compounds, the zingerines, from ginger rhizomes (Zingiber officinale Roscoe) using a phase-trafficking approach

Juan J. Araya; Huaping Zhang; Thomas E. Prisinzano; Lester A. Mitscher; Barbara N. Timmermann

doi:10.1016/j.phytochem.2011.03.007

Identification of unprecedented purine-containing compounds, the zingerines, from ginger rhizomes (Zingiber officinale Roscoe) using a phase-trafficking approach

Juan J. Araya, Huaping Zhang, Thomas E. Prisinzano, Lester A. Mitscher, Barbara N. Timmermann

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Three unprecedented purine-containing compounds, named [6]-, [8]-, and [10]-zingerines as they are 5-(6-amino-9H-purin-9-yl) analogs of [6]-, [8]-, and [10]-gingerols, respectively, were isolated from a methanolic extract of ginger rhizomes using a phase trafficking-based method that utilizes solid phase reagents allowing for fast and selective simultaneous separation of basic, acidic, and neutral components of natural products extracts.

Original language	English
Pages (from-to)	935-941
Number of pages	7
Journal	Phytochemistry
Volume	72
Issue number	9
DOIs	https://doi.org/10.1016/j.phytochem.2011.03.007
State	Published - Jun 2011

Bibliographical note

Funding Information:
The chemistry work was supported by NCCAM/ODS Grant 1R21AT004182-01A2 from the National Institutes of Health (NIH) and the University of Kansas Center for Research project 2506014-910/099 to B.N.T., J.A. thanks LASPAU-Fulbright program and the University of Costa Rica for financial support. J.A. also thanks Kimberly Lovell for assistance during chiral HPLC separations. The contents are solely the responsibilities of the authors and do not necessarily represent the official views of the NIH.

Keywords

Alkaloids
Fractionation
Ginger
Natural products
Phase-trafficking
Zingerines

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Plant Science
Horticulture

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10.1016/j.phytochem.2011.03.007

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title = "Identification of unprecedented purine-containing compounds, the zingerines, from ginger rhizomes (Zingiber officinale Roscoe) using a phase-trafficking approach",

abstract = "Three unprecedented purine-containing compounds, named [6]-, [8]-, and [10]-zingerines as they are 5-(6-amino-9H-purin-9-yl) analogs of [6]-, [8]-, and [10]-gingerols, respectively, were isolated from a methanolic extract of ginger rhizomes using a phase trafficking-based method that utilizes solid phase reagents allowing for fast and selective simultaneous separation of basic, acidic, and neutral components of natural products extracts.",

keywords = "Alkaloids, Fractionation, Ginger, Natural products, Phase-trafficking, Zingerines",

author = "Araya, {Juan J.} and Huaping Zhang and Prisinzano, {Thomas E.} and Mitscher, {Lester A.} and Timmermann, {Barbara N.}",

note = "Funding Information: The chemistry work was supported by NCCAM/ODS Grant 1R21AT004182-01A2 from the National Institutes of Health (NIH) and the University of Kansas Center for Research project 2506014-910/099 to B.N.T., J.A. thanks LASPAU-Fulbright program and the University of Costa Rica for financial support. J.A. also thanks Kimberly Lovell for assistance during chiral HPLC separations. The contents are solely the responsibilities of the authors and do not necessarily represent the official views of the NIH. ",

year = "2011",

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doi = "10.1016/j.phytochem.2011.03.007",

language = "English",

volume = "72",

pages = "935--941",

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AU - Araya, Juan J.

AU - Zhang, Huaping

AU - Prisinzano, Thomas E.

AU - Mitscher, Lester A.

AU - Timmermann, Barbara N.

N1 - Funding Information: The chemistry work was supported by NCCAM/ODS Grant 1R21AT004182-01A2 from the National Institutes of Health (NIH) and the University of Kansas Center for Research project 2506014-910/099 to B.N.T., J.A. thanks LASPAU-Fulbright program and the University of Costa Rica for financial support. J.A. also thanks Kimberly Lovell for assistance during chiral HPLC separations. The contents are solely the responsibilities of the authors and do not necessarily represent the official views of the NIH.

PY - 2011/6

Y1 - 2011/6

N2 - Three unprecedented purine-containing compounds, named [6]-, [8]-, and [10]-zingerines as they are 5-(6-amino-9H-purin-9-yl) analogs of [6]-, [8]-, and [10]-gingerols, respectively, were isolated from a methanolic extract of ginger rhizomes using a phase trafficking-based method that utilizes solid phase reagents allowing for fast and selective simultaneous separation of basic, acidic, and neutral components of natural products extracts.

AB - Three unprecedented purine-containing compounds, named [6]-, [8]-, and [10]-zingerines as they are 5-(6-amino-9H-purin-9-yl) analogs of [6]-, [8]-, and [10]-gingerols, respectively, were isolated from a methanolic extract of ginger rhizomes using a phase trafficking-based method that utilizes solid phase reagents allowing for fast and selective simultaneous separation of basic, acidic, and neutral components of natural products extracts.

KW - Alkaloids

KW - Fractionation

KW - Ginger

KW - Natural products

KW - Phase-trafficking

KW - Zingerines

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JO - Phytochemistry

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Identification of unprecedented purine-containing compounds, the zingerines, from ginger rhizomes (Zingiber officinale Roscoe) using a phase-trafficking approach

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

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