Identifying Potential Intervention Points for Acute Hypoglycemic Events in Patients with Type 2 Diabetes Using Retrospective Clinical Data

Mary E. Lacy; Rachel A. Whitmer; Sei J. Lee; Robert J. Rushakoff; Mark J. Pletcher

doi:10.2337/cd20-0057

Identifying Potential Intervention Points for Acute Hypoglycemic Events in Patients with Type 2 Diabetes Using Retrospective Clinical Data

Mary E. Lacy, Rachel A. Whitmer, Sei J. Lee, Robert J. Rushakoff, Mark J. Pletcher

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

This retrospective study examined changes in medication orders as a risk factor for future acute hypoglycemic events. The investigators identified factors associated with acute hypoglycemic events resulting in emergency department visits or inpatient admissions. Non-Hispanic Black race, chronic kidney disease, insulin at baseline, and nonprivate insurance were associated with higher risk of an acute hypoglycemic event, whereas age, sex, and A1C were not. After adjustment for other risk factors, changes in insulin orders after A1C measurement were associated with a 1.5 times higher risk of an acute hypoglycemia (adjusted hazard ratio 1.48, 95% CI 1.08–2.03). These results further understanding of risk factors and clinical processes relevant to predicting and preventing acute hypoglycemia.

Original language	English
Pages (from-to)	304-312
Number of pages	9
Journal	Clinical Diabetes
Volume	39
Issue number	3
DOIs	https://doi.org/10.2337/cd20-0057
State	Published - Jun 2021

Bibliographical note

Funding Information:
This work was supported by the National Institutes of Health (T32 AG049663 to M.E.L., KL2 TR001996 to M.E.L., R01 AG047500 to R.A.W., R01AG047897 to S.J.L., and R01AG057751 to S.J.L.) and the patient-Centered Outcomes Research Institute (PPRN-1306-04709 to M.E.L. and M.J.P.).

Publisher Copyright:
©2021 by the American Diabetes Association.

ASJC Scopus subject areas

Internal Medicine
Endocrinology, Diabetes and Metabolism

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10.2337/cd20-0057

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title = "Identifying Potential Intervention Points for Acute Hypoglycemic Events in Patients with Type 2 Diabetes Using Retrospective Clinical Data",

abstract = "This retrospective study examined changes in medication orders as a risk factor for future acute hypoglycemic events. The investigators identified factors associated with acute hypoglycemic events resulting in emergency department visits or inpatient admissions. Non-Hispanic Black race, chronic kidney disease, insulin at baseline, and nonprivate insurance were associated with higher risk of an acute hypoglycemic event, whereas age, sex, and A1C were not. After adjustment for other risk factors, changes in insulin orders after A1C measurement were associated with a 1.5 times higher risk of an acute hypoglycemia (adjusted hazard ratio 1.48, 95% CI 1.08–2.03). These results further understanding of risk factors and clinical processes relevant to predicting and preventing acute hypoglycemia.",

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note = "Funding Information: This work was supported by the National Institutes of Health (T32 AG049663 to M.E.L., KL2 TR001996 to M.E.L., R01 AG047500 to R.A.W., R01AG047897 to S.J.L., and R01AG057751 to S.J.L.) and the patient-Centered Outcomes Research Institute (PPRN-1306-04709 to M.E.L. and M.J.P.). Publisher Copyright: {\textcopyright}2021 by the American Diabetes Association.",

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AU - Lee, Sei J.

AU - Rushakoff, Robert J.

AU - Pletcher, Mark J.

N1 - Funding Information: This work was supported by the National Institutes of Health (T32 AG049663 to M.E.L., KL2 TR001996 to M.E.L., R01 AG047500 to R.A.W., R01AG047897 to S.J.L., and R01AG057751 to S.J.L.) and the patient-Centered Outcomes Research Institute (PPRN-1306-04709 to M.E.L. and M.J.P.). Publisher Copyright: ©2021 by the American Diabetes Association.

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Identifying Potential Intervention Points for Acute Hypoglycemic Events in Patients with Type 2 Diabetes Using Retrospective Clinical Data

Abstract

Bibliographical note

ASJC Scopus subject areas

UN SDGs

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