Abstract
Growing interest in post-traumatic brain plasticity events has fueled investigations of therapeutic approaches that promote endogenous neurorepair. Insulin-like growth factor-1 (IGF-1) is a polypeptide hormone with critical roles in regulating brain plasticity mechanisms. This chapter summarizes literature related to how expression of IGF-1 and its signaling components are altered after traumatic brain injury (TBI). To understand the potential effects of changes in endogenous IGF-1, the major roles of IGF-1 in CNS function are reviewed, with attention to how these IGF-mediated events may impact the response to TBI. In light of the multiplicity of CNS functions mediated by IGF-1, supplementation of endogenous IGF-1 may provide neuroprotection and promote neuronal repair in the injured brain. Coupled with a handful of preclinical studies in TBI, a larger literature in other CNS injuries such as stroke, hypoxic ischemia and spinal cord injury demonstrates potential beneficial effects of IGF-1 following injury.
Original language | English |
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Title of host publication | Brain Neurotrauma |
Subtitle of host publication | Molecular, Neuropsychological, and Rehabilitation Aspects |
Pages | 61-78 |
Number of pages | 18 |
ISBN (Electronic) | 9781466565999 |
DOIs | |
State | Published - Jan 1 2015 |
Bibliographical note
Publisher Copyright:© 2015 by Taylor & Francis Group, LLC.
ASJC Scopus subject areas
- General Neuroscience
- General Medicine