IGF-1/IGF-R signaling in traumatic brain injury: Impact on cell survival, neurogenesis, and behavioral outcome

Sindhu K. Madathil, Kathryn E. Saatman

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

40 Scopus citations

Abstract

Growing interest in post-traumatic brain plasticity events has fueled investigations of therapeutic approaches that promote endogenous neurorepair. Insulin-like growth factor-1 (IGF-1) is a polypeptide hormone with critical roles in regulating brain plasticity mechanisms. This chapter summarizes literature related to how expression of IGF-1 and its signaling components are altered after traumatic brain injury (TBI). To understand the potential effects of changes in endogenous IGF-1, the major roles of IGF-1 in CNS function are reviewed, with attention to how these IGF-mediated events may impact the response to TBI. In light of the multiplicity of CNS functions mediated by IGF-1, supplementation of endogenous IGF-1 may provide neuroprotection and promote neuronal repair in the injured brain. Coupled with a handful of preclinical studies in TBI, a larger literature in other CNS injuries such as stroke, hypoxic ischemia and spinal cord injury demonstrates potential beneficial effects of IGF-1 following injury.

Original languageEnglish
Title of host publicationBrain Neurotrauma
Subtitle of host publicationMolecular, Neuropsychological, and Rehabilitation Aspects
Pages61-78
Number of pages18
ISBN (Electronic)9781466565999
DOIs
StatePublished - Jan 1 2015

ASJC Scopus subject areas

  • Neuroscience (all)
  • Medicine (all)

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