IL-18 is not therapeutic for neovascular age-related macular degeneration

Yoshio Hirano; Tetsuhiro Yasuma; Takeshi Mizutani; Benjamin J. Fowler; Valeria Tarallo; Reo Yasuma; Younghee Kim; Ana Bastos-Carvalho; Nagaraj Kerur; Bradley D. Gelfand; Sasha Bogdanovich; Shikun He; Xiaohui Zhang; Miho Nozaki; Ryo Ijima; Hiroki Kaneko; Yuichiro Ogura; Hiroko Terasaki; Hiroshi Nagai; Isao Haro; Gabriel Núfez; Balamurali K. Ambati; David R. Hinton; Jayakrishna Ambati

doi:10.1038/nm.3671

IL-18 is not therapeutic for neovascular age-related macular degeneration

Yoshio Hirano, Tetsuhiro Yasuma, Takeshi Mizutani, Benjamin J. Fowler, Valeria Tarallo, Reo Yasuma, Younghee Kim, Ana Bastos-Carvalho, Nagaraj Kerur, Bradley D. Gelfand, Sasha Bogdanovich, Shikun He, Xiaohui Zhang, Miho Nozaki, Ryo Ijima, Hiroki Kaneko, Yuichiro Ogura, Hiroko Terasaki, Hiroshi Nagai, Isao HaroGabriel Núfez, Balamurali K. Ambati, David R. Hinton, Jayakrishna Ambati

Opthalmology

Research output: Contribution to journal › Letter › peer-review

37 Scopus citations

Original language	English
Pages (from-to)	1372-1375
Number of pages	4
Journal	Nature Medicine
Volume	20
Issue number	12
DOIs	https://doi.org/10.1038/nm.3671
State	Published - Dec 1 2014

Bibliographical note

Funding Information:
We thank L. Toll, G.R. Pattison R. King, L. Xu, M. McConnell, C. Payne, D. Robertson, G. Botzet, K. Ambati and A. Uittenbogaard for technical assistance. J.A. was supported by National Eye Institute/US National Institutes of Health (NIH) grants DP1GM114862, R01EY018350, R01EY018836, R01EY020672 and R01EY022238, the Doris Duke Distinguished Clinical Scientist Award, the Burroughs Wellcome Fund Clinical Scientist Award in Translational Research, the Ellison Medical Foundation Senior Scholar in Aging Award, the Dr. E. Vernon Smith and Eloise C. Smith Macular Degeneration Endowed Chair, a Foundation Fighting Blindness Individual Investigator Research Award, the Carl Reeves Foundation, a Harrington Discovery Institute Scholar-Innovator Award and a Research to Prevent Blindness departmental unrestricted grant. Y.H. was supported by an Alcon Japan Research award. T.Y. was supported by a Fight for Sight postdoctoral award. B.J.F. was supported by NIH T32HL091812 and UL1RR033173. A.B.-C. was supported by the Programme for Advanced Medical Education (sponsored by Fundação Calouste Gulbenkian, Fundação Champalimaud, Ministério da Saúde and Fundação para a Ciência e Tecnologia, Portugal) and a Bayer Global Ophthalmology Research Award. N.K. was supported by NIH K99EY024336 and the Beckman Initiative for Macular Research. B.D.G. was supported by the American Heart Association and the International Retinal Research Foundation. B.K.A. was supported by NIH R01EY017182 and R01EY017950, a Veterans Affairs Merit Award and the Department of Defense. G.N. was supported by NIH R01AI063331 and R01AR052756. D.R.H. was supported by NIH P30EY003040 and R01EY001545 and the Arnold and Mabel Beckman Foundation. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1038/nm.3671

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Hirano, Y., Yasuma, T., Mizutani, T., Fowler, B. J., Tarallo, V., Yasuma, R., Kim, Y., Bastos-Carvalho, A., Kerur, N., Gelfand, B. D., Bogdanovich, S., He, S., Zhang, X., Nozaki, M., Ijima, R., Kaneko, H., Ogura, Y., Terasaki, H., Nagai, H., ... Ambati, J. (2014). IL-18 is not therapeutic for neovascular age-related macular degeneration. Nature Medicine, 20(12), 1372-1375. https://doi.org/10.1038/nm.3671

@article{3dc94c6e554e4f458c38c68f22e03e8b,

title = "IL-18 is not therapeutic for neovascular age-related macular degeneration",

author = "Yoshio Hirano and Tetsuhiro Yasuma and Takeshi Mizutani and Fowler, {Benjamin J.} and Valeria Tarallo and Reo Yasuma and Younghee Kim and Ana Bastos-Carvalho and Nagaraj Kerur and Gelfand, {Bradley D.} and Sasha Bogdanovich and Shikun He and Xiaohui Zhang and Miho Nozaki and Ryo Ijima and Hiroki Kaneko and Yuichiro Ogura and Hiroko Terasaki and Hiroshi Nagai and Isao Haro and Gabriel N{\'u}fez and Ambati, {Balamurali K.} and Hinton, {David R.} and Jayakrishna Ambati",

note = "Funding Information: We thank L. Toll, G.R. Pattison R. King, L. Xu, M. McConnell, C. Payne, D. Robertson, G. Botzet, K. Ambati and A. Uittenbogaard for technical assistance. J.A. was supported by National Eye Institute/US National Institutes of Health (NIH) grants DP1GM114862, R01EY018350, R01EY018836, R01EY020672 and R01EY022238, the Doris Duke Distinguished Clinical Scientist Award, the Burroughs Wellcome Fund Clinical Scientist Award in Translational Research, the Ellison Medical Foundation Senior Scholar in Aging Award, the Dr. E. Vernon Smith and Eloise C. Smith Macular Degeneration Endowed Chair, a Foundation Fighting Blindness Individual Investigator Research Award, the Carl Reeves Foundation, a Harrington Discovery Institute Scholar-Innovator Award and a Research to Prevent Blindness departmental unrestricted grant. Y.H. was supported by an Alcon Japan Research award. T.Y. was supported by a Fight for Sight postdoctoral award. B.J.F. was supported by NIH T32HL091812 and UL1RR033173. A.B.-C. was supported by the Programme for Advanced Medical Education (sponsored by Funda{\c c}{\~a}o Calouste Gulbenkian, Funda{\c c}{\~a}o Champalimaud, Minist{\'e}rio da Sa{\'u}de and Funda{\c c}{\~a}o para a Ci{\^e}ncia e Tecnologia, Portugal) and a Bayer Global Ophthalmology Research Award. N.K. was supported by NIH K99EY024336 and the Beckman Initiative for Macular Research. B.D.G. was supported by the American Heart Association and the International Retinal Research Foundation. B.K.A. was supported by NIH R01EY017182 and R01EY017950, a Veterans Affairs Merit Award and the Department of Defense. G.N. was supported by NIH R01AI063331 and R01AR052756. D.R.H. was supported by NIH P30EY003040 and R01EY001545 and the Arnold and Mabel Beckman Foundation. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.",

year = "2014",

month = dec,

day = "1",

doi = "10.1038/nm.3671",

language = "English",

volume = "20",

pages = "1372--1375",

number = "12",

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Hirano, Y, Yasuma, T, Mizutani, T, Fowler, BJ, Tarallo, V, Yasuma, R, Kim, Y, Bastos-Carvalho, A, Kerur, N, Gelfand, BD, Bogdanovich, S, He, S, Zhang, X, Nozaki, M, Ijima, R, Kaneko, H, Ogura, Y, Terasaki, H, Nagai, H, Haro, I, Núfez, G, Ambati, BK, Hinton, DR & Ambati, J 2014, 'IL-18 is not therapeutic for neovascular age-related macular degeneration', Nature Medicine, vol. 20, no. 12, pp. 1372-1375. https://doi.org/10.1038/nm.3671

TY - JOUR

T1 - IL-18 is not therapeutic for neovascular age-related macular degeneration

AU - Hirano, Yoshio

AU - Yasuma, Tetsuhiro

AU - Mizutani, Takeshi

AU - Fowler, Benjamin J.

AU - Tarallo, Valeria

AU - Yasuma, Reo

AU - Kim, Younghee

AU - Bastos-Carvalho, Ana

AU - Kerur, Nagaraj

AU - Gelfand, Bradley D.

AU - Bogdanovich, Sasha

AU - He, Shikun

AU - Zhang, Xiaohui

AU - Nozaki, Miho

AU - Ijima, Ryo

AU - Kaneko, Hiroki

AU - Ogura, Yuichiro

AU - Terasaki, Hiroko

AU - Nagai, Hiroshi

AU - Haro, Isao

AU - Núfez, Gabriel

AU - Ambati, Balamurali K.

AU - Hinton, David R.

AU - Ambati, Jayakrishna

N1 - Funding Information: We thank L. Toll, G.R. Pattison R. King, L. Xu, M. McConnell, C. Payne, D. Robertson, G. Botzet, K. Ambati and A. Uittenbogaard for technical assistance. J.A. was supported by National Eye Institute/US National Institutes of Health (NIH) grants DP1GM114862, R01EY018350, R01EY018836, R01EY020672 and R01EY022238, the Doris Duke Distinguished Clinical Scientist Award, the Burroughs Wellcome Fund Clinical Scientist Award in Translational Research, the Ellison Medical Foundation Senior Scholar in Aging Award, the Dr. E. Vernon Smith and Eloise C. Smith Macular Degeneration Endowed Chair, a Foundation Fighting Blindness Individual Investigator Research Award, the Carl Reeves Foundation, a Harrington Discovery Institute Scholar-Innovator Award and a Research to Prevent Blindness departmental unrestricted grant. Y.H. was supported by an Alcon Japan Research award. T.Y. was supported by a Fight for Sight postdoctoral award. B.J.F. was supported by NIH T32HL091812 and UL1RR033173. A.B.-C. was supported by the Programme for Advanced Medical Education (sponsored by Fundação Calouste Gulbenkian, Fundação Champalimaud, Ministério da Saúde and Fundação para a Ciência e Tecnologia, Portugal) and a Bayer Global Ophthalmology Research Award. N.K. was supported by NIH K99EY024336 and the Beckman Initiative for Macular Research. B.D.G. was supported by the American Heart Association and the International Retinal Research Foundation. B.K.A. was supported by NIH R01EY017182 and R01EY017950, a Veterans Affairs Merit Award and the Department of Defense. G.N. was supported by NIH R01AI063331 and R01AR052756. D.R.H. was supported by NIH P30EY003040 and R01EY001545 and the Arnold and Mabel Beckman Foundation. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.

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Y1 - 2014/12/1

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DO - 10.1038/nm.3671

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C2 - 25473914

AN - SCOPUS:84909605289

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EP - 1375

JO - Nature Medicine

JF - Nature Medicine

IS - 12

ER -

IL-18 is not therapeutic for neovascular age-related macular degeneration

Bibliographical note

ASJC Scopus subject areas

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