Abstract
Oxidized LDL induces changes in several facets of the immune system, although the relationships between these facets and their contributions to atherogenesis have yet to be fully elucidated. A report in this issue of the JCI provides a novel demonstration of the adaptive immune system influencing the production of natural antibodies. The results demonstrate that injection of malondialdehyde-modified LDL promotes a Th2 response that in turn increases the titers of the natural antibody T15/EO6, which recognizes the oxidized phospholipid POVPC. Atherosclerotic lesion size in LDL receptor-deficient mice is reduced as a consequence of the increase in natural antibody titers, and IL-5 is identified as the link between the adaptive and natural immune systems (see related article beginning on page 427).
| Original language | English |
|---|---|
| Pages (from-to) | 317-319 |
| Number of pages | 3 |
| Journal | Journal of Clinical Investigation |
| Volume | 114 |
| Issue number | 3 |
| DOIs | |
| State | Published - Aug 2004 |
ASJC Scopus subject areas
- General Medicine
Fingerprint
Dive into the research topics of 'IL-5 links adaptive and natural immunity in reducing atherosclerotic disease'. Together they form a unique fingerprint.Cite this
- APA
- Author
- BIBTEX
- Harvard
- Standard
- RIS
- Vancouver