IL-lβ inhibits TGFβ in the temporomandibular joint

W. H. Lim, J. Toothman, J. H. Miller, R. H. Tallents, S. M. Brouxhon, M. E. Olschowka, S. Kyrkanides

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Similarly to humans, healthy, wild-type mice develop osteoarthritis, including of the temporomandibular joint (TMJ), as a result of aging. Pro-inflammatory cytokines, such as IL-1β, IL-6, and TNF α, are known to contribute to the development of osteoarthritis, whereas TGFβ has been associated with articular regeneration. We hypothesized that a balance between IL-1 β and TGFβ underlies the development of TMJ osteoarthritis, whereby IL-1 β signaling down- regulates TGFβ expression as part of disease pathology. Our studies in wild-type mice, as well as the Col1-IL1βXAT mouse model of osteoarthritis, demonstrated an inverse correlation between IL-1 β and TGFβ expression in the TMJ. IL-1 β etiologically correlated with joint pathology, whereas TGFβ expression associated with IL-1 β down-regulation and improvement of articular pathology. Better understanding of the underlying inflammatory processes during disease will potentially enable us to harness inflammation for orofacial tissue regeneration.

Original languageEnglish
Pages (from-to)557-562
Number of pages6
JournalJournal of Dental Research
Volume88
Issue number6
DOIs
StatePublished - Jun 1 2009

Funding

FundersFunder number
National Institute of Dental and Craniofacial ResearchR21DE017765
National Institute of Dental and Craniofacial Research

    Keywords

    • Il-1β
    • Tgfβ
    • Tmj pathology

    ASJC Scopus subject areas

    • General Dentistry

    Fingerprint

    Dive into the research topics of 'IL-lβ inhibits TGFβ in the temporomandibular joint'. Together they form a unique fingerprint.

    Cite this