Imaging proteins in membranes of living cells by high-resolution scanning ion conductance microscopy

Andrew I. Shevchuk, Gregory I. Frolenkov, Daniel Sánchez, Peter S. James, Noah Freedman, Max J. Lab, Roy Jones, David Klenerman, Yuri E. Korchev

Research output: Contribution to journalArticlepeer-review

187 Scopus citations

Abstract

Do not touch! The surface of a living cell is soft and responsive and therefore high-resolution imaging of the cell membrane has not been possible to date. Now noncontact imaging of protein complexes in the plasma membrane of living cells has been demonstrated (see picture) and has been used to follow the cells' structural reorganization. This breakthrough opens up a wealth of new experiments in membrane and cell biology. (Figure Presented)

Original languageEnglish
Pages (from-to)2212-2216
Number of pages5
JournalAngewandte Chemie - International Edition
Volume45
Issue number14
DOIs
StatePublished - Mar 27 2006

Keywords

  • Cells
  • Imaging
  • Membrane proteins
  • Membranes
  • Scanning probe microscopy

ASJC Scopus subject areas

  • Catalysis
  • General Chemistry

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