Imipramine treatment of ADHD in a fragile X child

David K. Hilton, Catherine A. Martin, William M. Heffron, Bryan D. Hall, Gregory L. Johnson

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Fragile X syndrome, an X-linked genetic disorder, is the third most common cause of mental retardation. The following is a case of a 6-year-old boy with fragile X syndrome and its characteristic cognitive and behavioral symptomatology, including attention deficit hyperactivity disorder. In addition, this child experienced initial insomnia and nocturnal enuresis, problems not previously reported with fragile X. Previous pharmacological treatment of the syndrome's behavioral difficulties and attention deficit has included stimulants, folic acid, and neuroleptics. This is the first report of the successful use of imipramine. Imipramine also improved the boy's insomnia and enuresis, whereas methylphenidate caused an overall worsening of his condition.

Original languageEnglish
Pages (from-to)831-834
Number of pages4
JournalJournal of the American Academy of Child and Adolescent Psychiatry
Issue number5
StatePublished - 1991


  • ADHD
  • Martin-Bell syndrome
  • fragile X syndrome
  • imipramine

ASJC Scopus subject areas

  • Developmental and Educational Psychology
  • Psychiatry and Mental health


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