TY - JOUR
T1 - Imipramine treatment of ADHD in a fragile X child
AU - Hilton, David K.
AU - Martin, Catherine A.
AU - Heffron, William M.
AU - Hall, Bryan D.
AU - Johnson, Gregory L.
PY - 1991
Y1 - 1991
N2 - Fragile X syndrome, an X-linked genetic disorder, is the third most common cause of mental retardation. The following is a case of a 6-year-old boy with fragile X syndrome and its characteristic cognitive and behavioral symptomatology, including attention deficit hyperactivity disorder. In addition, this child experienced initial insomnia and nocturnal enuresis, problems not previously reported with fragile X. Previous pharmacological treatment of the syndrome's behavioral difficulties and attention deficit has included stimulants, folic acid, and neuroleptics. This is the first report of the successful use of imipramine. Imipramine also improved the boy's insomnia and enuresis, whereas methylphenidate caused an overall worsening of his condition.
AB - Fragile X syndrome, an X-linked genetic disorder, is the third most common cause of mental retardation. The following is a case of a 6-year-old boy with fragile X syndrome and its characteristic cognitive and behavioral symptomatology, including attention deficit hyperactivity disorder. In addition, this child experienced initial insomnia and nocturnal enuresis, problems not previously reported with fragile X. Previous pharmacological treatment of the syndrome's behavioral difficulties and attention deficit has included stimulants, folic acid, and neuroleptics. This is the first report of the successful use of imipramine. Imipramine also improved the boy's insomnia and enuresis, whereas methylphenidate caused an overall worsening of his condition.
KW - ADHD
KW - Martin-Bell syndrome
KW - fragile X syndrome
KW - imipramine
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U2 - 10.1016/S0890-8567(10)80024-3
DO - 10.1016/S0890-8567(10)80024-3
M3 - Article
C2 - 1938802
AN - SCOPUS:0026003277
SN - 0890-8567
VL - 30
SP - 831
EP - 834
JO - Journal of the American Academy of Child and Adolescent Psychiatry
JF - Journal of the American Academy of Child and Adolescent Psychiatry
IS - 5
ER -