Introduction: Large cell neuroendocrine carcinomas (LCNEC) are a group of rare high grade neuroendocrine tumors that often behave clinically like small cell carcinoma (SCLC) and are treated as such. No major advancement in the management of these tumors has occurred in the last 30 years. Methods: We present a case series of three cases from Markey Cancer center along with a review of 13 published cases in the literature wherein immune-checkpoint inhibitors were utilized in the management of LCNEC. Results: Immune-checkpoint inhibitors might have clinical activity in LCNEC. Conclusion: Role of immune-checkpoint inhibitors should be explored in prospective LCNEC clinical trials. We summarize current evidence regarding use of immune checkpoint inhibitors in the treatment of LCNEC.

Original languageEnglish
Pages (from-to)14738-14740
Number of pages3
Issue number18
StatePublished - 2018

Bibliographical note

Publisher Copyright:
© Chauhan et al.


  • High grade neuroendocrine carcinoma
  • Immune checkpoint inhibitors
  • Large cell neuroendocrine carcinoma

ASJC Scopus subject areas

  • Oncology


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