Immunohistochemical localization of prostaglandin endoperoxide synthase in human fetal membranes and decidua

T. M. Price, S. W. Kauma, T. E. Curry, M. R. Clark

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


Prostaglandins play an important role during the maintenance of pregnancy and the initiation of parturition. Prostaglandin endoperoxide synthase activity has been demonstrated in human fetal membranes and decidua. Using immunohistochemical techniques, we identified in these tissues the cell types that contain prostaglandin endoperoxide synthase. A total of 33 specimens, ranging from 8 wk to 42 wk gestation, were studied. Decidualized stromal cells stained the most intensely and consistently of all cell types. Cytotrophoblast of the chorion and early placental villi and syncytotrophoblast of all gestational ages demonstrated a lighter, more variable staining pattern. Regardless of gestational age, amnion stained in a heterogeneous fashion, with some cells demonstrating an intense staining and other cells having no staining. There were no observable differences in laboring compared to nonlaboring term specimens. In summary, the specific cell types that contain immunoreactive prostaglandin endoperoxide synthase have been identified in fetal membranes and decidua.

Original languageEnglish
Pages (from-to)701-705
Number of pages5
JournalBiology of Reproduction
Issue number4
StatePublished - 1989

ASJC Scopus subject areas

  • Reproductive Medicine
  • Cell Biology


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