Immunohistochemical staining for CA-125 in fallopian tube carcinomas

L. E. Puls; D. D. Davey; P. D. DePriest; H. H. Gallion; J. R. Van Nagell; J. E. Hunter; E. J. Pavlik

doi:10.1006/gyno.1993.1063

Immunohistochemical staining for CA-125 in fallopian tube carcinomas

L. E. Puls, D. D. Davey, P. D. DePriest, H. H. Gallion, J. R. Van Nagell, J. E. Hunter, E. J. Pavlik

Obstetrics and Gynecology

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

From 1981-1991, 15 patients with primary fallopian tube carcinomas were treated at the University of Kentucky Medical Center. Immunohistochemical staining for CA-125 was performed on tumor specimens from all cases. Thirteen tumors (87%) stained positively for CA-125. Antigen staining was most intense in the apical portions of carcinoma cells. Serum CA-125 levels were measured in 5 patients and were elevated in 4 (80%). There was a positive correlation between tumor and serum antigen expression in these cases. Serum CA-125 levels accurately reflected disease status in the patients studied. These data suggest that CA-125 is a useful marker in patients with fallopian tube carcinoma. Immunohistochemical localization of CA-125 in tumor tissue should predict which patients will benefit most from serial antigen determinations.

Original language	English
Pages (from-to)	360-363
Number of pages	4
Journal	Gynecologic Oncology
Volume	48
Issue number	3
DOIs	https://doi.org/10.1006/gyno.1993.1063
State	Published - Mar 1993

ASJC Scopus subject areas

Oncology
Obstetrics and Gynecology

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10.1006/gyno.1993.1063

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title = "Immunohistochemical staining for CA-125 in fallopian tube carcinomas",

abstract = "From 1981-1991, 15 patients with primary fallopian tube carcinomas were treated at the University of Kentucky Medical Center. Immunohistochemical staining for CA-125 was performed on tumor specimens from all cases. Thirteen tumors (87%) stained positively for CA-125. Antigen staining was most intense in the apical portions of carcinoma cells. Serum CA-125 levels were measured in 5 patients and were elevated in 4 (80%). There was a positive correlation between tumor and serum antigen expression in these cases. Serum CA-125 levels accurately reflected disease status in the patients studied. These data suggest that CA-125 is a useful marker in patients with fallopian tube carcinoma. Immunohistochemical localization of CA-125 in tumor tissue should predict which patients will benefit most from serial antigen determinations.",

author = "Puls, {L. E.} and Davey, {D. D.} and DePriest, {P. D.} and Gallion, {H. H.} and {Van Nagell}, {J. R.} and Hunter, {J. E.} and Pavlik, {E. J.}",

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doi = "10.1006/gyno.1993.1063",

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T1 - Immunohistochemical staining for CA-125 in fallopian tube carcinomas

AU - Puls, L. E.

AU - Davey, D. D.

AU - DePriest, P. D.

AU - Gallion, H. H.

AU - Van Nagell, J. R.

AU - Hunter, J. E.

AU - Pavlik, E. J.

PY - 1993/3

Y1 - 1993/3

N2 - From 1981-1991, 15 patients with primary fallopian tube carcinomas were treated at the University of Kentucky Medical Center. Immunohistochemical staining for CA-125 was performed on tumor specimens from all cases. Thirteen tumors (87%) stained positively for CA-125. Antigen staining was most intense in the apical portions of carcinoma cells. Serum CA-125 levels were measured in 5 patients and were elevated in 4 (80%). There was a positive correlation between tumor and serum antigen expression in these cases. Serum CA-125 levels accurately reflected disease status in the patients studied. These data suggest that CA-125 is a useful marker in patients with fallopian tube carcinoma. Immunohistochemical localization of CA-125 in tumor tissue should predict which patients will benefit most from serial antigen determinations.

AB - From 1981-1991, 15 patients with primary fallopian tube carcinomas were treated at the University of Kentucky Medical Center. Immunohistochemical staining for CA-125 was performed on tumor specimens from all cases. Thirteen tumors (87%) stained positively for CA-125. Antigen staining was most intense in the apical portions of carcinoma cells. Serum CA-125 levels were measured in 5 patients and were elevated in 4 (80%). There was a positive correlation between tumor and serum antigen expression in these cases. Serum CA-125 levels accurately reflected disease status in the patients studied. These data suggest that CA-125 is a useful marker in patients with fallopian tube carcinoma. Immunohistochemical localization of CA-125 in tumor tissue should predict which patients will benefit most from serial antigen determinations.

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Immunohistochemical staining for CA-125 in fallopian tube carcinomas

Abstract

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