Immunohistochemical staining for CA-125 in fallopian tube carcinomas

L. E. Puls; D. D. Davey; P. D. DePriest; H. H. Gallion; J. R. Van Nagell; J. E. Hunter; E. J. Pavlik

doi:10.1006/gyno.1993.1063

Immunohistochemical staining for CA-125 in fallopian tube carcinomas

L. E. Puls, D. D. Davey, P. D. DePriest, H. H. Gallion, J. R. Van Nagell, J. E. Hunter, E. J. Pavlik

Obstetrics and Gynecology

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24 Scopus citations

Abstract

From 1981-1991, 15 patients with primary fallopian tube carcinomas were treated at the University of Kentucky Medical Center. Immunohistochemical staining for CA-125 was performed on tumor specimens from all cases. Thirteen tumors (87%) stained positively for CA-125. Antigen staining was most intense in the apical portions of carcinoma cells. Serum CA-125 levels were measured in 5 patients and were elevated in 4 (80%). There was a positive correlation between tumor and serum antigen expression in these cases. Serum CA-125 levels accurately reflected disease status in the patients studied. These data suggest that CA-125 is a useful marker in patients with fallopian tube carcinoma. Immunohistochemical localization of CA-125 in tumor tissue should predict which patients will benefit most from serial antigen determinations.

Original language	English
Pages (from-to)	360-363
Number of pages	4
Journal	Gynecologic Oncology
Volume	48
Issue number	3
DOIs	https://doi.org/10.1006/gyno.1993.1063
State	Published - Mar 1993

ASJC Scopus subject areas

Oncology
Obstetrics and Gynecology

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10.1006/gyno.1993.1063

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title = "Immunohistochemical staining for CA-125 in fallopian tube carcinomas",

abstract = "From 1981-1991, 15 patients with primary fallopian tube carcinomas were treated at the University of Kentucky Medical Center. Immunohistochemical staining for CA-125 was performed on tumor specimens from all cases. Thirteen tumors (87\%) stained positively for CA-125. Antigen staining was most intense in the apical portions of carcinoma cells. Serum CA-125 levels were measured in 5 patients and were elevated in 4 (80\%). There was a positive correlation between tumor and serum antigen expression in these cases. Serum CA-125 levels accurately reflected disease status in the patients studied. These data suggest that CA-125 is a useful marker in patients with fallopian tube carcinoma. Immunohistochemical localization of CA-125 in tumor tissue should predict which patients will benefit most from serial antigen determinations.",

author = "Puls, \{L. E.\} and Davey, \{D. D.\} and DePriest, \{P. D.\} and Gallion, \{H. H.\} and \{Van Nagell\}, \{J. R.\} and Hunter, \{J. E.\} and Pavlik, \{E. J.\}",

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doi = "10.1006/gyno.1993.1063",

language = "English",

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T1 - Immunohistochemical staining for CA-125 in fallopian tube carcinomas

AU - Puls, L. E.

AU - Davey, D. D.

AU - DePriest, P. D.

AU - Gallion, H. H.

AU - Van Nagell, J. R.

AU - Hunter, J. E.

AU - Pavlik, E. J.

PY - 1993/3

Y1 - 1993/3

N2 - From 1981-1991, 15 patients with primary fallopian tube carcinomas were treated at the University of Kentucky Medical Center. Immunohistochemical staining for CA-125 was performed on tumor specimens from all cases. Thirteen tumors (87%) stained positively for CA-125. Antigen staining was most intense in the apical portions of carcinoma cells. Serum CA-125 levels were measured in 5 patients and were elevated in 4 (80%). There was a positive correlation between tumor and serum antigen expression in these cases. Serum CA-125 levels accurately reflected disease status in the patients studied. These data suggest that CA-125 is a useful marker in patients with fallopian tube carcinoma. Immunohistochemical localization of CA-125 in tumor tissue should predict which patients will benefit most from serial antigen determinations.

AB - From 1981-1991, 15 patients with primary fallopian tube carcinomas were treated at the University of Kentucky Medical Center. Immunohistochemical staining for CA-125 was performed on tumor specimens from all cases. Thirteen tumors (87%) stained positively for CA-125. Antigen staining was most intense in the apical portions of carcinoma cells. Serum CA-125 levels were measured in 5 patients and were elevated in 4 (80%). There was a positive correlation between tumor and serum antigen expression in these cases. Serum CA-125 levels accurately reflected disease status in the patients studied. These data suggest that CA-125 is a useful marker in patients with fallopian tube carcinoma. Immunohistochemical localization of CA-125 in tumor tissue should predict which patients will benefit most from serial antigen determinations.

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Immunohistochemical staining for CA-125 in fallopian tube carcinomas

Abstract

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