Skip to main navigation Skip to search Skip to main content

Immunohistochemical staining of cholinergic neurons in the human brain using a polyclonal antibody to human choline acetyltransferase

  • Dwight C. German
  • , Gordon Bruce
  • , Louis B. Hersh

Research output: Contribution to journalArticlepeer-review

96 Scopus citations

Abstract

Antibodies against human placental choline acetyltransferase (ChAT) were used to immunohistochemically stain cholinergic neurons in the neostriatum and nucleus basalis of Meynert in human brain. Cells in both regions were intensely stained as were nerve fibers. Comparable cells were stained in these same brain regions in the rat. This anti-human ChAT antibody will enable the further detailed characterization of cholinergic neurons in the human brain in both health and disease.

Original languageEnglish
Pages (from-to)1-5
Number of pages5
JournalNeuroscience Letters
Volume61
Issue number1-2
DOIs
StatePublished - Oct 24 1985

Funding

FundersFunder number
National Institute of Neurological Disorders and StrokeR01NS015739

    UN SDGs

    This output contributes to the following UN Sustainable Development Goals (SDGs)

    1. SDG 3 - Good Health and Well-being
      SDG 3 Good Health and Well-being

    Keywords

    • choline acetyltransferase
    • human brain
    • immunohistochemistry

    ASJC Scopus subject areas

    • General Neuroscience

    Fingerprint

    Dive into the research topics of 'Immunohistochemical staining of cholinergic neurons in the human brain using a polyclonal antibody to human choline acetyltransferase'. Together they form a unique fingerprint.

    Cite this