Immunosenescence of the Equine Immune System

D. W. Horohov; A. A. Adams; T. M. Chambers

doi:10.1016/j.jcpa.2009.10.007

Immunosenescence of the Equine Immune System

D. W. Horohov, A. A. Adams, T. M. Chambers

Veterinary Science

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

It is widely recognized that advanced age is associated with alterations in immunological responses that likely contribute to increased morbidity and mortality in the elderly population. This decreased efficacy of the immune system with age is referred to as 'immunosenescence' and has been reported for a number of species. Similar age-related changes are seen in horses and are manifested as decreased responsiveness to vaccination in vivo and diminished proliferative responses to mitogens in vitro. The underlying mechanism responsible for these impaired immunological responses remains unknown. This paper reviews some of our recent findings on immunosenescence in horses. Recent results on the immune response of aged horses to vaccination with a novel recombinant influenza vaccine are also discussed.

Original language	English
Pages (from-to)	S78-S84
Journal	Journal of Comparative Pathology
Volume	142
Issue number	SUPPL. 1
DOIs	https://doi.org/10.1016/j.jcpa.2009.10.007
State	Published - Jan 2010

Bibliographical note

Funding Information:
The vaccine study was supported by Merial, Ltd. Special thanks to the Department of Veterinary Science for additional technical support. Special thanks to Dr. T. Sturgill for providing veterinary care.

Keywords

horse
immunosenescence
vaccine

ASJC Scopus subject areas

Pathology and Forensic Medicine
General Veterinary

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jcpa.2009.10.007

Cite this

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title = "Immunosenescence of the Equine Immune System",

abstract = "It is widely recognized that advanced age is associated with alterations in immunological responses that likely contribute to increased morbidity and mortality in the elderly population. This decreased efficacy of the immune system with age is referred to as 'immunosenescence' and has been reported for a number of species. Similar age-related changes are seen in horses and are manifested as decreased responsiveness to vaccination in vivo and diminished proliferative responses to mitogens in vitro. The underlying mechanism responsible for these impaired immunological responses remains unknown. This paper reviews some of our recent findings on immunosenescence in horses. Recent results on the immune response of aged horses to vaccination with a novel recombinant influenza vaccine are also discussed.",

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AU - Adams, A. A.

AU - Chambers, T. M.

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AB - It is widely recognized that advanced age is associated with alterations in immunological responses that likely contribute to increased morbidity and mortality in the elderly population. This decreased efficacy of the immune system with age is referred to as 'immunosenescence' and has been reported for a number of species. Similar age-related changes are seen in horses and are manifested as decreased responsiveness to vaccination in vivo and diminished proliferative responses to mitogens in vitro. The underlying mechanism responsible for these impaired immunological responses remains unknown. This paper reviews some of our recent findings on immunosenescence in horses. Recent results on the immune response of aged horses to vaccination with a novel recombinant influenza vaccine are also discussed.

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Immunosenescence of the Equine Immune System

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

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