Impact of 2,3,7,8-tetrachlorodibenzo-p-dioxin on cutaneous wound healing

Valentina Moirangthem, Wendy S. Katz, Wen Su, Eun Young Choi, R. W.Cameron Dingle, Georgia M. Zeigler, William V. Everson, C. Darrell Jennings, Ming Gong, Hollie I. Swanson

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a representative of a large group of polyhalogenated aromatic hydrocarbons that are widespread environmental contaminants. Administration of TCDD to laboratory animals or cultured cells results in a number of adverse effects that are well documented. For example, the effects of TCDD observed in developing organisms indicate that exposure to this class of environmental contaminants significantly alters embryo morphogenesis. However, it is not clear whether tissue regeneration in adult animals may be similarly affected. With this in mind, we examined the impact of TCDD exposure on wound healing using a murine cutaneous wound healing model. Our results indicate that TCDD exposure did not significantly alter the time needed for wound closure. However, in the TCDD-treated mice, a significant decrease in tensile strength in the healed wounds was observed which is indicative of an aberrantly healed wound. Immunostaining revealed that exposure to TCDD increased the population of macrophages detected within the wounded tissue at the latter stages of wound healing. Our findings support the idea that exposure to environmental contaminants such as TCDD is proinflammatory in the wounded tissue, disrupts normal healing and ultimately produces in a poorly healed wound.

Original languageEnglish
Pages (from-to)61-67
Number of pages7
JournalExperimental and Toxicologic Pathology
Issue number1-2
StatePublished - Jan 2013

Bibliographical note

Funding Information:
We are very grateful to the Steve Post and Eric Smart laboratories for their guidance in the wound healing protocols, to Linda Zimmerman for her assistance with the microscopy and immunohistochemistry and to Donna Gilbreath for her assistance with graphics. We also thank Dr. Robert Hadley and Dr. Michael Piascik for their insights and assistance in editing. This work was supported by grants from the National Institute of Environmental Health ( R01 ES 014849 and R01 ES011295 ).


  • 2,3,7,8-Tetrachlorodibenzo-p-dioxin
  • Extracellular matrix remodeling
  • Macrophages
  • Skin
  • Tensile strength
  • Wound healing

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Toxicology
  • Cell Biology


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