Impact of abdominal visceral fat, growth hormone, fitness, and insulin on lipids and lipoproteins in older adults.

Arthur Weltman; Jean Pierre Despres; Jody L. Clasey; Judy Y. Weltman; Laurie Wideman; Jill Kanaley; James Patrie; Jean Bergeron; Michael O. Thorner; Claude Bouchard; Mark L. Hartman

doi:10.1053/meta.2003.50007

Impact of abdominal visceral fat, growth hormone, fitness, and insulin on lipids and lipoproteins in older adults.

Arthur Weltman, Jean Pierre Despres, Jody L. Clasey, Judy Y. Weltman, Laurie Wideman, Jill Kanaley, James Patrie, Jean Bergeron, Michael O. Thorner, Claude Bouchard, Mark L. Hartman

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

We examined the relationship between abdominal visceral fat (AVF) and plasma concentrations of lipids and lipoproteins in 19 females (F) (not on estrogen) and 31 males (M) over the age of 60 (age = 66.8 years). In addition, the effects of growth hormone (GH) release, fitness (Vo(2) peak), insulin, and glucose concentrations (both fasting and in response to an oral glucose tolerance test) on lipids were examined. Subjects were categorized by low (L) and high (H) AVF (L < 130 cm(2), H > 130 cm(2)), fat mass (FM) (above or below median value), and AVF corrected for fat mass. Factorial analysis of variance (ANOVA) showed that when subjects were divided by AVF and FM, similar results were observed with H > L (P <.05) for very-low-density lipoprotein-cholesterol (VLDL-C), triglycerides (TG), VLDL-TG, apolipoprotein (apo)-B, apo-B VLDL, cholesterol (Chol)/high-density lipoprotein (HDL), LDL/HDL, apoB/A1 and L > H for HDL, HDL(2), HDL(3), apo A1, and LDL/apo-B LDL. Gender differences were also observed with F > M for Chol, LDL, HDL, and HDL(2). When AVF was corrected for FM, these gender differences were still present. After correcting for FM, differences remained between H and L AVF groups for VLDL, TG, VLDL-TG, apo-B, apo-B LDL, apo-B VLDL, apoB/A1 (P <.05). Twenty-four hour integrated GH concentration (IGHC) was inversely related to VLDL, TG, VLDL TG, LDL TG, apoB, apoB VLDL, apoB LDL, Chol/HDL, LDL/HDL, and apoB/A1 in F, but not M (P <.05). Vo(2) peak was directly related to Chol, LDL, HDL(3), and apoB LDL with stronger relationships observed in F. Fasting insulin was related to lipids and lipoproteins in both men and women. These data suggest that, in older adults, elevated levels of AVF, FM, and AVF corrected for FM are associated with unfavorable lipid-lipoprotein profiles and extend similar findings reported in younger males and females with elevated AVF. These data also support previous findings indicating that AVF is a primary determinant of GH release.

Original language	English
Pages (from-to)	73-80
Number of pages	8
Journal	Metabolism: Clinical and Experimental
Volume	52
Issue number	1
DOIs	https://doi.org/10.1053/meta.2003.50007
State	Published - Jan 2003

Bibliographical note

Funding Information:
From the Departments of Human Services, Medicine, and Health Evaluation Sciences, University of Virginia, Charlottesville, VA; Departments of Medicine, Food Science and Nutrition, and Lipid Research Center, Laval University, Ste.-Foy, Quebec, Canada; and the Pennington Biomedical Research Center, Baton Rouge, LA. Submitted April 5, 2002; accepted July 23, 2002. Supported in part by National Institutes of Health (NIH) Grant No. RO1-AG-10997 (to M.L.H.) and by General Clinical Research Center (GCRC) Grant No. NIH-RR-00847. Presented in part at the 8th International Congress on Obesity, Paris, France, August 29-September 3, 1998; and at the International Symposium on Endocrinology of Aging, Tempe, AZ, October 27-30, 1999. Address reprint requests to Arthur Weltman, PhD, Exercise Physiology Laboratory/Memorial Gym, University of Virginia, Charlottesville, VA 22903. Copyright 2003, Elsevier Science (USA). All rights reserved. 0026-0495/03/5201-0008$35.00/0 doi:10.1053/meta.2003.50007

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1053/meta.2003.50007

Cite this

Weltman, A., Despres, J. P., Clasey, J. L., Weltman, J. Y., Wideman, L., Kanaley, J., Patrie, J., Bergeron, J., Thorner, M. O., Bouchard, C., & Hartman, M. L. (2003). Impact of abdominal visceral fat, growth hormone, fitness, and insulin on lipids and lipoproteins in older adults. Metabolism: Clinical and Experimental, 52(1), 73-80. https://doi.org/10.1053/meta.2003.50007

@article{09222e12696b4f4581fb493fd809d77c,

title = "Impact of abdominal visceral fat, growth hormone, fitness, and insulin on lipids and lipoproteins in older adults.",

abstract = "We examined the relationship between abdominal visceral fat (AVF) and plasma concentrations of lipids and lipoproteins in 19 females (F) (not on estrogen) and 31 males (M) over the age of 60 (age = 66.8 years). In addition, the effects of growth hormone (GH) release, fitness (Vo(2) peak), insulin, and glucose concentrations (both fasting and in response to an oral glucose tolerance test) on lipids were examined. Subjects were categorized by low (L) and high (H) AVF (L < 130 cm(2), H > 130 cm(2)), fat mass (FM) (above or below median value), and AVF corrected for fat mass. Factorial analysis of variance (ANOVA) showed that when subjects were divided by AVF and FM, similar results were observed with H > L (P <.05) for very-low-density lipoprotein-cholesterol (VLDL-C), triglycerides (TG), VLDL-TG, apolipoprotein (apo)-B, apo-B VLDL, cholesterol (Chol)/high-density lipoprotein (HDL), LDL/HDL, apoB/A1 and L > H for HDL, HDL(2), HDL(3), apo A1, and LDL/apo-B LDL. Gender differences were also observed with F > M for Chol, LDL, HDL, and HDL(2). When AVF was corrected for FM, these gender differences were still present. After correcting for FM, differences remained between H and L AVF groups for VLDL, TG, VLDL-TG, apo-B, apo-B LDL, apo-B VLDL, apoB/A1 (P <.05). Twenty-four hour integrated GH concentration (IGHC) was inversely related to VLDL, TG, VLDL TG, LDL TG, apoB, apoB VLDL, apoB LDL, Chol/HDL, LDL/HDL, and apoB/A1 in F, but not M (P <.05). Vo(2) peak was directly related to Chol, LDL, HDL(3), and apoB LDL with stronger relationships observed in F. Fasting insulin was related to lipids and lipoproteins in both men and women. These data suggest that, in older adults, elevated levels of AVF, FM, and AVF corrected for FM are associated with unfavorable lipid-lipoprotein profiles and extend similar findings reported in younger males and females with elevated AVF. These data also support previous findings indicating that AVF is a primary determinant of GH release.",

author = "Arthur Weltman and Despres, {Jean Pierre} and Clasey, {Jody L.} and Weltman, {Judy Y.} and Laurie Wideman and Jill Kanaley and James Patrie and Jean Bergeron and Thorner, {Michael O.} and Claude Bouchard and Hartman, {Mark L.}",

note = "Funding Information: From the Departments of Human Services, Medicine, and Health Evaluation Sciences, University of Virginia, Charlottesville, VA; Departments of Medicine, Food Science and Nutrition, and Lipid Research Center, Laval University, Ste.-Foy, Quebec, Canada; and the Pennington Biomedical Research Center, Baton Rouge, LA. Submitted April 5, 2002; accepted July 23, 2002. Supported in part by National Institutes of Health (NIH) Grant No. RO1-AG-10997 (to M.L.H.) and by General Clinical Research Center (GCRC) Grant No. NIH-RR-00847. Presented in part at the 8th International Congress on Obesity, Paris, France, August 29-September 3, 1998; and at the International Symposium on Endocrinology of Aging, Tempe, AZ, October 27-30, 1999. Address reprint requests to Arthur Weltman, PhD, Exercise Physiology Laboratory/Memorial Gym, University of Virginia, Charlottesville, VA 22903. Copyright 2003, Elsevier Science (USA). All rights reserved. 0026-0495/03/5201-0008$35.00/0 doi:10.1053/meta.2003.50007",

year = "2003",

month = jan,

doi = "10.1053/meta.2003.50007",

language = "English",

volume = "52",

pages = "73--80",

number = "1",

}

TY - JOUR

T1 - Impact of abdominal visceral fat, growth hormone, fitness, and insulin on lipids and lipoproteins in older adults.

AU - Weltman, Arthur

AU - Despres, Jean Pierre

AU - Clasey, Jody L.

AU - Weltman, Judy Y.

AU - Wideman, Laurie

AU - Kanaley, Jill

AU - Patrie, James

AU - Bergeron, Jean

AU - Thorner, Michael O.

AU - Bouchard, Claude

AU - Hartman, Mark L.

N1 - Funding Information: From the Departments of Human Services, Medicine, and Health Evaluation Sciences, University of Virginia, Charlottesville, VA; Departments of Medicine, Food Science and Nutrition, and Lipid Research Center, Laval University, Ste.-Foy, Quebec, Canada; and the Pennington Biomedical Research Center, Baton Rouge, LA. Submitted April 5, 2002; accepted July 23, 2002. Supported in part by National Institutes of Health (NIH) Grant No. RO1-AG-10997 (to M.L.H.) and by General Clinical Research Center (GCRC) Grant No. NIH-RR-00847. Presented in part at the 8th International Congress on Obesity, Paris, France, August 29-September 3, 1998; and at the International Symposium on Endocrinology of Aging, Tempe, AZ, October 27-30, 1999. Address reprint requests to Arthur Weltman, PhD, Exercise Physiology Laboratory/Memorial Gym, University of Virginia, Charlottesville, VA 22903. Copyright 2003, Elsevier Science (USA). All rights reserved. 0026-0495/03/5201-0008$35.00/0 doi:10.1053/meta.2003.50007

PY - 2003/1

Y1 - 2003/1

N2 - We examined the relationship between abdominal visceral fat (AVF) and plasma concentrations of lipids and lipoproteins in 19 females (F) (not on estrogen) and 31 males (M) over the age of 60 (age = 66.8 years). In addition, the effects of growth hormone (GH) release, fitness (Vo(2) peak), insulin, and glucose concentrations (both fasting and in response to an oral glucose tolerance test) on lipids were examined. Subjects were categorized by low (L) and high (H) AVF (L < 130 cm(2), H > 130 cm(2)), fat mass (FM) (above or below median value), and AVF corrected for fat mass. Factorial analysis of variance (ANOVA) showed that when subjects were divided by AVF and FM, similar results were observed with H > L (P <.05) for very-low-density lipoprotein-cholesterol (VLDL-C), triglycerides (TG), VLDL-TG, apolipoprotein (apo)-B, apo-B VLDL, cholesterol (Chol)/high-density lipoprotein (HDL), LDL/HDL, apoB/A1 and L > H for HDL, HDL(2), HDL(3), apo A1, and LDL/apo-B LDL. Gender differences were also observed with F > M for Chol, LDL, HDL, and HDL(2). When AVF was corrected for FM, these gender differences were still present. After correcting for FM, differences remained between H and L AVF groups for VLDL, TG, VLDL-TG, apo-B, apo-B LDL, apo-B VLDL, apoB/A1 (P <.05). Twenty-four hour integrated GH concentration (IGHC) was inversely related to VLDL, TG, VLDL TG, LDL TG, apoB, apoB VLDL, apoB LDL, Chol/HDL, LDL/HDL, and apoB/A1 in F, but not M (P <.05). Vo(2) peak was directly related to Chol, LDL, HDL(3), and apoB LDL with stronger relationships observed in F. Fasting insulin was related to lipids and lipoproteins in both men and women. These data suggest that, in older adults, elevated levels of AVF, FM, and AVF corrected for FM are associated with unfavorable lipid-lipoprotein profiles and extend similar findings reported in younger males and females with elevated AVF. These data also support previous findings indicating that AVF is a primary determinant of GH release.

AB - We examined the relationship between abdominal visceral fat (AVF) and plasma concentrations of lipids and lipoproteins in 19 females (F) (not on estrogen) and 31 males (M) over the age of 60 (age = 66.8 years). In addition, the effects of growth hormone (GH) release, fitness (Vo(2) peak), insulin, and glucose concentrations (both fasting and in response to an oral glucose tolerance test) on lipids were examined. Subjects were categorized by low (L) and high (H) AVF (L < 130 cm(2), H > 130 cm(2)), fat mass (FM) (above or below median value), and AVF corrected for fat mass. Factorial analysis of variance (ANOVA) showed that when subjects were divided by AVF and FM, similar results were observed with H > L (P <.05) for very-low-density lipoprotein-cholesterol (VLDL-C), triglycerides (TG), VLDL-TG, apolipoprotein (apo)-B, apo-B VLDL, cholesterol (Chol)/high-density lipoprotein (HDL), LDL/HDL, apoB/A1 and L > H for HDL, HDL(2), HDL(3), apo A1, and LDL/apo-B LDL. Gender differences were also observed with F > M for Chol, LDL, HDL, and HDL(2). When AVF was corrected for FM, these gender differences were still present. After correcting for FM, differences remained between H and L AVF groups for VLDL, TG, VLDL-TG, apo-B, apo-B LDL, apo-B VLDL, apoB/A1 (P <.05). Twenty-four hour integrated GH concentration (IGHC) was inversely related to VLDL, TG, VLDL TG, LDL TG, apoB, apoB VLDL, apoB LDL, Chol/HDL, LDL/HDL, and apoB/A1 in F, but not M (P <.05). Vo(2) peak was directly related to Chol, LDL, HDL(3), and apoB LDL with stronger relationships observed in F. Fasting insulin was related to lipids and lipoproteins in both men and women. These data suggest that, in older adults, elevated levels of AVF, FM, and AVF corrected for FM are associated with unfavorable lipid-lipoprotein profiles and extend similar findings reported in younger males and females with elevated AVF. These data also support previous findings indicating that AVF is a primary determinant of GH release.

UR - http://www.scopus.com/inward/record.url?scp=18144452003&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=18144452003&partnerID=8YFLogxK

U2 - 10.1053/meta.2003.50007

DO - 10.1053/meta.2003.50007

M3 - Article

C2 - 12524665

AN - SCOPUS:18144452003

SN - 0026-0495

VL - 52

SP - 73

EP - 80

JO - Metabolism: Clinical and Experimental

JF - Metabolism: Clinical and Experimental

IS - 1

ER -

Impact of abdominal visceral fat, growth hormone, fitness, and insulin on lipids and lipoproteins in older adults.

Abstract

Bibliographical note

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this