Abstract
Objectives.: To evaluate the association between body mass index (BMI) and outcomes in women with advanced or recurrent endometrial cancer treated with doxorubicin/cisplatin. Methods.: Data from patients treated on five Gynecologic Oncology Group trials were retrospectively reviewed. BMI was categorized as normal (< 25), overweight (≥ 25 to < 30), obese (≥ 30 to < 40), and morbidly obese (≥ 40). BMI was analyzed for associations with demographics, clinical characteristics, toxicity, progression-free survival (PFS), and overall survival (OS). Results.: Among 949 patients, 533 (56%) had recurrent disease, 227 (23.9%) had Stage IV disease, and 189 (19.9%) had Stage III disease. Mean BMI was 29.8; 29.6%, 27.0%, 33.2% and 10.2% of patients, respectively, were categorized as normal, overweight, obese, and morbidly obese. The mean BMI was significantly different when compared by age group (p < 0.001), stage (p = 0.047), histologic type (p = 0.024), and tumor grade (p = 0.014). Older patients and those with clear cell, poorly differentiated tumors, or stage IV disease had a lower BMI. No significant associations between PFS and BMI were detected. Increasing BMI was significantly associated with an increased risk of death in Stage III/IV (HR = 1.86, 95% CI 1.16-2.99 for BMI ≥ 40 vs. BMI < 25) but not recurrent patients. Higher BMI patients had less Grade 3/4 toxicities than normal patients (p < 0.001) but this difference disappeared for obese patients receiving ≥ 95% of the calculated dose. Conclusions.: BMI was not predictive of PFS in this endometrial cancer population although morbidly obese patients had decreased OS in primary Stage III/IV patients. Toxicities decreased with increasing BMI, perhaps secondary to capped dosing.
Original language | English |
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Pages (from-to) | 59-65 |
Number of pages | 7 |
Journal | Gynecologic Oncology |
Volume | 105 |
Issue number | 1 |
DOIs | |
State | Published - Apr 2007 |
Bibliographical note
Funding Information:This study was supported by National Cancer Institute grants to the Gynecologic Oncology Group (GOG) Administrative Office (CA 27469) and the GOG Statistical and Data Center (CA 37517), and by a Building Interdisciplinary Research Careers in Women's Health (BIRCWH) Scholarship.
Keywords
- Endometrial cancer
- Lower uterine segment
- Nodal disease
- Prognosis
ASJC Scopus subject areas
- Oncology
- Obstetrics and Gynecology