Impact of body mass index on treatment outcomes in endometrial cancer patients receiving doxorubicin and cisplatin: A Gynecologic Oncology Group study

Susan C. Modesitt, Chunqiao Tian, Richard Kryscio, J. Tate Thigpen, Marcus E. Randall, Holly H. Gallion, Gini F. Fleming

Research output: Contribution to journalArticlepeer-review

49 Scopus citations


Objectives.: To evaluate the association between body mass index (BMI) and outcomes in women with advanced or recurrent endometrial cancer treated with doxorubicin/cisplatin. Methods.: Data from patients treated on five Gynecologic Oncology Group trials were retrospectively reviewed. BMI was categorized as normal (< 25), overweight (≥ 25 to < 30), obese (≥ 30 to < 40), and morbidly obese (≥ 40). BMI was analyzed for associations with demographics, clinical characteristics, toxicity, progression-free survival (PFS), and overall survival (OS). Results.: Among 949 patients, 533 (56%) had recurrent disease, 227 (23.9%) had Stage IV disease, and 189 (19.9%) had Stage III disease. Mean BMI was 29.8; 29.6%, 27.0%, 33.2% and 10.2% of patients, respectively, were categorized as normal, overweight, obese, and morbidly obese. The mean BMI was significantly different when compared by age group (p < 0.001), stage (p = 0.047), histologic type (p = 0.024), and tumor grade (p = 0.014). Older patients and those with clear cell, poorly differentiated tumors, or stage IV disease had a lower BMI. No significant associations between PFS and BMI were detected. Increasing BMI was significantly associated with an increased risk of death in Stage III/IV (HR = 1.86, 95% CI 1.16-2.99 for BMI ≥ 40 vs. BMI < 25) but not recurrent patients. Higher BMI patients had less Grade 3/4 toxicities than normal patients (p < 0.001) but this difference disappeared for obese patients receiving ≥ 95% of the calculated dose. Conclusions.: BMI was not predictive of PFS in this endometrial cancer population although morbidly obese patients had decreased OS in primary Stage III/IV patients. Toxicities decreased with increasing BMI, perhaps secondary to capped dosing.

Original languageEnglish
Pages (from-to)59-65
Number of pages7
JournalGynecologic Oncology
Issue number1
StatePublished - Apr 2007

Bibliographical note

Funding Information:
This study was supported by National Cancer Institute grants to the Gynecologic Oncology Group (GOG) Administrative Office (CA 27469) and the GOG Statistical and Data Center (CA 37517), and by a Building Interdisciplinary Research Careers in Women's Health (BIRCWH) Scholarship.


  • Endometrial cancer
  • Lower uterine segment
  • Nodal disease
  • Prognosis

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynecology


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